Modulation of the hydrogen bonding structure of water by renal osmolytes

Pramod Kumar Verma, Hochan Lee, Joon Young Park, Joon Hyung Lim, Michał Maj, Jun Ho Choi, Kyungwon Kwak, Minhaeng Cho

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Osmolytes are an integral part of living organism, e.g., the kidney uses sorbitol, trimethylglycine, taurine and myo-inositol to counter the deleterious effects of urea and salt. Therefore, knowing that the osmolytes' act either directly to the protein or mediated through water is of great importance. Our experimental and computational results show that protecting osmolytes, e.g., trimethylglycine and sorbitol, significantly modulate the water H-bonding network structure, although the magnitude and spatial extent of osmolyte-induced perturbation greatly vary. In contrast, urea behaves neutrally toward local water H-bonding network. Protecting osmolytes studied here show strong concentration-dependent behaviors (vibrational frequencies and lifetimes of two different infrared (IR) probes), while denaturant does not. The H-bond donor and/or acceptor (OH/NH) in a given osmolyte molecule play a critical role in defining their action. Our findings highlight the significance of the alteration of H-bonding network of water under biologically relevant environment, often encountered in real biological systems.

Original languageEnglish
Pages (from-to)2273-2279
Number of pages7
JournalJournal of Physical Chemistry Letters
Volume6
Issue number14
DOIs
Publication statusPublished - 2015 Jul 16

Fingerprint

Hydrogen Bonding
Hydrogen bonds
Modulation
Kidney
Sorbitol
Water
Urea
Hydrogen
Taurine
Vibrational spectra
Inositol
Biological systems
Salts
Infrared radiation
Proteins
Molecules

Keywords

  • hydrogen bonding
  • infrared pump-probe
  • MD simulation
  • orientational relaxation
  • population relaxation
  • renal osmolyte
  • vibrational spectroscopy

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Modulation of the hydrogen bonding structure of water by renal osmolytes. / Verma, Pramod Kumar; Lee, Hochan; Park, Joon Young; Lim, Joon Hyung; Maj, Michał; Choi, Jun Ho; Kwak, Kyungwon; Cho, Minhaeng.

In: Journal of Physical Chemistry Letters, Vol. 6, No. 14, 16.07.2015, p. 2273-2279.

Research output: Contribution to journalArticle

Verma, Pramod Kumar ; Lee, Hochan ; Park, Joon Young ; Lim, Joon Hyung ; Maj, Michał ; Choi, Jun Ho ; Kwak, Kyungwon ; Cho, Minhaeng. / Modulation of the hydrogen bonding structure of water by renal osmolytes. In: Journal of Physical Chemistry Letters. 2015 ; Vol. 6, No. 14. pp. 2273-2279.
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