Molecular and phylogenetic analyses of influenza B viruses isolated from pediatric inpatients in South Korea during the 2011–2012 winter season

Jeong Hyun Nam, Eun Jung Song, Daesub Song, Erica Españo, Sang Mu Shim, Seo Hee Jeong, Robert G. Webster, Woo Joo Kim, Jeong Ki Kim

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    1 Citation (Scopus)

    Abstract

    Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011–2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein.

    Original languageEnglish
    Article number000983
    Pages (from-to)2950-2954
    Number of pages5
    JournalJournal of General Virology
    Volume98
    Issue number12
    DOIs
    Publication statusPublished - 2017 Dec

    Keywords

    • Influenza B virus
    • Molecular characterization
    • Phylogenetic analysis

    ASJC Scopus subject areas

    • Virology

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