Abstract
Sequence analyses of the entire small hydrophobic (SH) and hemagglutinin-neuraminidase (HN) genes of mumps viruses circulated in Korea from 1998 to 2001 showed that these isolates were grouped into two genotypes, H and I. While genotype I was predominant throughout the country during this period, genotype H was found in the restricted region, 1999. The nucleotide and deduced amino acid sequences of Korean isolates showed the type-specific changes including the signature motif at positions 28-30 in the SH gene and the neutralizing epitopes in the HN gene. Particularly, Asian strains including Korean isolates and European strains differed from 2.3 to 3.8% at the nucleotide sequence level in the SH gene although they belonged to the same genotype H. Furthermore, none of Korean isolates were genetically related to the vaccine strains used in Korea. The results provide important information to understand the epidemiology of mumps infection and to facilitate the development of more efficient vaccine program in Korea.
| Original language | English |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Virus Research |
| Volume | 97 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 Nov 1 |
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Keywords
- Hemagglutinin- neuraminidase gene
- Mumps virus
- Sequence analysis
- Small hydrophobic gene
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Virology
Cite this
Molecular characterization of two genotypes of mumps virus circulated in Korea during 1998-2001. / Lee, Joo Yeon; Kim, Yoon Young; Shin, Gu Choul; Na, Byoung Kuk; Lee, Jin Soo; Lee, Ho Dong; Kim, Jee Hee; Kim, Woo Joo; Kim, Joon; Kang, Chun; Cho, Hae Wol.
In: Virus Research, Vol. 97, No. 2, 01.11.2003, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular characterization of two genotypes of mumps virus circulated in Korea during 1998-2001
AU - Lee, Joo Yeon
AU - Kim, Yoon Young
AU - Shin, Gu Choul
AU - Na, Byoung Kuk
AU - Lee, Jin Soo
AU - Lee, Ho Dong
AU - Kim, Jee Hee
AU - Kim, Woo Joo
AU - Kim, Joon
AU - Kang, Chun
AU - Cho, Hae Wol
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Sequence analyses of the entire small hydrophobic (SH) and hemagglutinin-neuraminidase (HN) genes of mumps viruses circulated in Korea from 1998 to 2001 showed that these isolates were grouped into two genotypes, H and I. While genotype I was predominant throughout the country during this period, genotype H was found in the restricted region, 1999. The nucleotide and deduced amino acid sequences of Korean isolates showed the type-specific changes including the signature motif at positions 28-30 in the SH gene and the neutralizing epitopes in the HN gene. Particularly, Asian strains including Korean isolates and European strains differed from 2.3 to 3.8% at the nucleotide sequence level in the SH gene although they belonged to the same genotype H. Furthermore, none of Korean isolates were genetically related to the vaccine strains used in Korea. The results provide important information to understand the epidemiology of mumps infection and to facilitate the development of more efficient vaccine program in Korea.
AB - Sequence analyses of the entire small hydrophobic (SH) and hemagglutinin-neuraminidase (HN) genes of mumps viruses circulated in Korea from 1998 to 2001 showed that these isolates were grouped into two genotypes, H and I. While genotype I was predominant throughout the country during this period, genotype H was found in the restricted region, 1999. The nucleotide and deduced amino acid sequences of Korean isolates showed the type-specific changes including the signature motif at positions 28-30 in the SH gene and the neutralizing epitopes in the HN gene. Particularly, Asian strains including Korean isolates and European strains differed from 2.3 to 3.8% at the nucleotide sequence level in the SH gene although they belonged to the same genotype H. Furthermore, none of Korean isolates were genetically related to the vaccine strains used in Korea. The results provide important information to understand the epidemiology of mumps infection and to facilitate the development of more efficient vaccine program in Korea.
KW - Hemagglutinin- neuraminidase gene
KW - Mumps virus
KW - Sequence analysis
KW - Small hydrophobic gene
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UR - http://www.scopus.com/inward/citedby.url?scp=10744227042&partnerID=8YFLogxK
U2 - 10.1016/j.virusres.2003.08.006
DO - 10.1016/j.virusres.2003.08.006
M3 - Article
VL - 97
SP - 111
EP - 116
JO - Virus Research
JF - Virus Research
SN - 0168-1702
IS - 2
ER -