Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity

Chul Hyun Cho, Joung Ho Moon, Ho-Kyoung Yoon, Seung Gul Kang, Dongho Geum, Gi Hoon Son, Jong Min Lim, Leen Kim, Eun Il Lee, Heon-Jeong Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study examined the link between circadian rhythm changes due to bright light exposure and subthreshold bipolarity. Molecular circadian rhythms, polysomnography, and actigraphy data were studied in 25 young, healthy male subjects, divided into high and low mood disorder questionnaire (MDQ) score groups. During the first 2 days of the study, the subjects were exposed to daily-living light (150 lux) for 4 hours before bedtime. Saliva and buccal cells were collected 5 times a day for 2 consecutive days. During the subsequent 5 days, the subjects were exposed to bright light (1,000 lux), and saliva and buccal cell samples were collected in the same way. Molecular circadian rhythms were analyzed using sine regression. Circadian rhythms of cortisol (F = 16.956, p < 0.001) and relative PER1/ARNTL gene expression (F = 122.1, p < 0.001) showed a delayed acrophase in both groups after bright light exposure. The high MDQ score group showed a significant delay in acrophase compared to the low MDQ score group only in salivary cortisol (F = 8.528, p = 0.008). The high MDQ score group showed hypersensitivity in cortisol rhythm shift after bright light exposure, suggesting characteristic molecular circadian rhythm changes in the high MDQ score group may be related to biological processes downstream from core circadian clock gene expression.

Original languageEnglish
Article number31846
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Aug 22

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Circadian Rhythm
Mood Disorders
Light
Hydrocortisone
Cheek
Saliva
Actigraphy
Biological Phenomena
Gene Expression
Circadian Clocks
Polysomnography
Healthy Volunteers
Hypersensitivity
Surveys and Questionnaires

ASJC Scopus subject areas

  • General

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Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity. / Cho, Chul Hyun; Moon, Joung Ho; Yoon, Ho-Kyoung; Kang, Seung Gul; Geum, Dongho; Son, Gi Hoon; Lim, Jong Min; Kim, Leen; Lee, Eun Il; Lee, Heon-Jeong.

In: Scientific Reports, Vol. 6, 31846, 22.08.2016.

Research output: Contribution to journalArticle

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AU - Geum, Dongho

AU - Son, Gi Hoon

AU - Lim, Jong Min

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