Molecular cloning and expression analysis of CD82 in pig

Kyu Won Cho, Jong Gun Kim, Kwang Youn Whang, Woon Won Jung, Young Bong Kim

Research output: Contribution to journalArticle

Abstract

CD82, which was originally referred to as KAI1 (kangai 1), is a member of the tetraspanin protein family, which contains four transmembrane domains. CD82 is implicated in a variety of biological processes, including apoptosis, cell adhesion, and cell migration. In this study, the full-length cDNA of pig CD82 was cloned and sequenced. Pig Cd82 cDNA contains an open reading frame (801 bp) encoding 266 amino acids. Sequence alignment results indicated that pig CD82 cDNA evidenced 85.45%, 85.63%, 77.03%, and 77.78% identity with human, cattle, rat, and mouse, respectively. In the expression study, the constitutive expression of swine Cd82 mRNA was detected in a variety of tissues, including lymphoid tissues as well as nonlymphoid tissues. Future studies will be focused on the functional role of CD82 during the course of pig infectious diseases or tumor development.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalAnimal Biotechnology
Volume19
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Bioengineering

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