Molecular coevolution of kisspeptins and their receptors from fish to mammals

Haet Nim Um, Ji Man Han, Jong-Ik Hwang, Sung In Hong, Hubert Vaudry, Jae Young Seong

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Kisspeptin and its receptor, GPR54, play a pivotal role in vertebrate reproduction. Recent advances in bioinformatic tools combined with comparative genomics have led to the identification of a large number of kisspeptin and GPR54 genes in a variety of vertebrate species. Genome duplications may have produced at least two isoforms of both ligand (KiSS1 and KiSS2) and receptor (GPR54-1 and GPR54-2). Additional isoforms of kisspeptin (KiSS1b) and GPR54 (GPR54-1b) have been found in an amphibian species, Xenopus (Silurana) tropicalis. Here, we describe the evolutionary lineages of these kisspeptin and GPR54 isoforms using genome synteny and phylogenetic analyses, and possible molecular interactions between kisspeptin and GPR54 subtypes based on ligand-receptor selectivity. Together, kisspeptin and GPR54 provide an excellent model for understanding molecular coevolution of the peptide ligand and GPCR pairs.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1200
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Kisspeptins
Mammals
Fish
Fishes
Protein Isoforms
Genes
Ligands
Vertebrates
Genome
Synteny
Molecular Models
Molecular interactions
Amphibians
Bioinformatics
Xenopus
Genomics
Computational Biology
Reproduction
Coevolution
Peptides

Keywords

  • G protein-coupled receptor
  • genome synteny
  • GPR54, evolution
  • kisspeptin
  • phylogentic analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Molecular coevolution of kisspeptins and their receptors from fish to mammals. / Um, Haet Nim; Han, Ji Man; Hwang, Jong-Ik; Hong, Sung In; Vaudry, Hubert; Seong, Jae Young.

In: Annals of the New York Academy of Sciences, Vol. 1200, 01.07.2010, p. 67-74.

Research output: Contribution to journalArticle

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