TY - JOUR
T1 - Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control
AU - Cho, Hyo Min
AU - Sun, Woong
N1 - Funding Information:
This research was supported by the Brain Research Program through the National Research Foundation (NRF) funded by the Korean Ministry of Science, ICT & Future Planning (NRF-2015M3C7A1028790, NRF-2017M3A9B3061308, and NRF-2018R1A2A3075271).
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.
AB - Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.
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U2 - 10.1038/s12276-020-0434-9
DO - 10.1038/s12276-020-0434-9
M3 - Review article
C2 - 32398745
AN - SCOPUS:85084514771
VL - 52
SP - 730
EP - 737
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
SN - 1226-3613
IS - 5
ER -