Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Hyo Min Cho, Woong Sun

Research output: Contribution to journalReview article

Abstract

Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.

Original languageEnglish
JournalExperimental and Molecular Medicine
DOIs
Publication statusAccepted/In press - 2020 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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