Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Xiaoxia Hu, Haiying Chen, Meishan Jin, Xianfu Wang, Jiyun Lee, Weihong Xu, Rui Zhang, Shibo Li, Junqi Niu

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

Original languageEnglish
Article number26
JournalMolecular Cytogenetics
Volume5
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Cytogenetic anomalies
  • FISH
  • TP53 mutation
  • Undifferentiated embryonal sarcoma of the liver (UESL)
  • aCGH

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Biochemistry, medical

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