Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Xiaoxia Hu; Haiying Chen; Meishan Jin; Xianfu Wang; Jiyun Lee; Weihong Xu; Rui Zhang; Shibo Li; Junqi Niu

doi:10.1186/1755-8166-5-26

Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Xiaoxia Hu, Haiying Chen, Meishan Jin, Xianfu Wang, Jiyun Lee, Weihong Xu, Rui Zhang, Shibo Li, Junqi Niu

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

Original language	English
Article number	26
Journal	Molecular Cytogenetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/1755-8166-5-26
Publication status	Published - 2012
Externally published	Yes

Keywords

Cytogenetic anomalies
FISH
TP53 mutation
Undifferentiated embryonal sarcoma of the liver (UESL)
aCGH

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)
Biochemistry, medical

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10.1186/1755-8166-5-26

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title = "Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review",

abstract = "Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.",

keywords = "Cytogenetic anomalies, FISH, TP53 mutation, Undifferentiated embryonal sarcoma of the liver (UESL), aCGH",

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T1 - Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver

T2 - A case report and literature review

AU - Hu, Xiaoxia

AU - Chen, Haiying

AU - Jin, Meishan

AU - Wang, Xianfu

AU - Lee, Jiyun

AU - Xu, Weihong

AU - Zhang, Rui

AU - Li, Shibo

AU - Niu, Junqi

PY - 2012

Y1 - 2012

N2 - Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

AB - Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

KW - Cytogenetic anomalies

KW - FISH

KW - TP53 mutation

KW - Undifferentiated embryonal sarcoma of the liver (UESL)

KW - aCGH

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DO - 10.1186/1755-8166-5-26

M3 - Review article

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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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