Abstract
Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
| Original language | English |
|---|---|
| Article number | 26 |
| Journal | Molecular Cytogenetics |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- Cytogenetic anomalies
- FISH
- TP53 mutation
- Undifferentiated embryonal sarcoma of the liver (UESL)
- aCGH
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Genetics
- Genetics(clinical)
- Biochemistry, medical
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Cite this
Hu, X., Chen, H., Jin, M., Wang, X., Lee, J., Xu, W., Zhang, R., Li, S., & Niu, J. (2012). Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review. Molecular Cytogenetics, 5(1), [26]. https://doi.org/10.1186/1755-8166-5-26