Abstract
Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
| Original language | English |
|---|---|
| Article number | 26 |
| Journal | Molecular Cytogenetics |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 May 4 |
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Keywords
- aCGH
- Cytogenetic anomalies
- FISH
- TP53 mutation
- Undifferentiated embryonal sarcoma of the liver (UESL)
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Genetics
- Genetics(clinical)
- Biochemistry, medical
Cite this
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver : A case report and literature review. / Hu, Xiaoxia; Chen, Haiying; Jin, Meishan; Wang, Xianfu; Lee, Ji-Yun; Xu, Weihong; Zhang, Rui; Li, Shibo; Niu, Junqi.
In: Molecular Cytogenetics, Vol. 5, No. 1, 26, 04.05.2012.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver
T2 - A case report and literature review
AU - Hu, Xiaoxia
AU - Chen, Haiying
AU - Jin, Meishan
AU - Wang, Xianfu
AU - Lee, Ji-Yun
AU - Xu, Weihong
AU - Zhang, Rui
AU - Li, Shibo
AU - Niu, Junqi
PY - 2012/5/4
Y1 - 2012/5/4
N2 - Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
AB - Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
KW - aCGH
KW - Cytogenetic anomalies
KW - FISH
KW - TP53 mutation
KW - Undifferentiated embryonal sarcoma of the liver (UESL)
UR - http://www.scopus.com/inward/record.url?scp=84860363047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860363047&partnerID=8YFLogxK
U2 - 10.1186/1755-8166-5-26
DO - 10.1186/1755-8166-5-26
M3 - Review article
C2 - 22551002
AN - SCOPUS:84860363047
VL - 5
JO - Molecular Cytogenetics
JF - Molecular Cytogenetics
SN - 1755-8166
IS - 1
M1 - 26
ER -