Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Xiaoxia Hu; Haiying Chen; Meishan Jin; Xianfu Wang; Jiyun Lee; Weihong Xu; Rui Zhang; Shibo Li; Junqi Niu

doi:10.1186/1755-8166-5-26

Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: A case report and literature review

Xiaoxia Hu, Haiying Chen, Meishan Jin, Xianfu Wang, Jiyun Lee, Weihong Xu, Rui Zhang, Shibo Li, Junqi Niu

Department of Pathology

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

Original language	English
Article number	26
Journal	Molecular Cytogenetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/1755-8166-5-26
Publication status	Published - 2012

Keywords

Cytogenetic anomalies
FISH
TP53 mutation
Undifferentiated embryonal sarcoma of the liver (UESL)
aCGH

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)
Biochemistry, medical

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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver : A case report and literature review. / Hu, Xiaoxia; Chen, Haiying; Jin, Meishan; Wang, Xianfu; Lee, Jiyun; Xu, Weihong; Zhang, Rui; Li, Shibo; Niu, Junqi.

In: Molecular Cytogenetics, Vol. 5, No. 1, 26, 2012.

Research output: Contribution to journal › Review article › peer-review

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