Abstract
Purpose: This study investigated the clinical epidemiology, antimicrobial susceptibility, and molecular epidemiology of Corynebacterium striatum isolates. Patients and methods: An observational study was conducted at a university hospital in the Republic of Korea from August to December 2016. All subjects were patients who tested positive for C. striatum clinically. Clinical data were analyzed to evaluate the microbiological and genotypic characteristics of C. striatum strains. Results: Sixty-seven C. striatum isolates recovered from non-duplicated patients were characterized. Patients were classified into three groups according to the infection type: nosocomial infection (71.6%), health care-associated infection (8.7%), and community-acquired infection (18.8%). The most common clinical specimens were urine (35.8%) and skin abscesses (32.8%). Fifty-two (77.6%) isolates showed multidrug resistance, defined as resistance to ≥3 different antibiotic families. All strains were susceptible to vancomycin and linezolid. Resistance to other antibiotics varied: penicillin (n=65; 97.0%), ampicillin (n=63; 94.0%), cefotaxime (n=64; 95.5%), and levofloxacin (n=61; 91.0%). Phylogenetic analysis identified all 16 S rRNA gene sequences of the 67 isolates as those of C. striatum, where 98%–99% were homologous to C. striatum ATCC 6940. In multilocus sequence typing for internal transcribed spacer region, gyrA, and rpoB sequencing, the most predominant sequence types (STs) were ST2, ST3, ST6, and ST5. Conclusion: C. striatum isolates may cause opportunistic infections associated with nosocomial infections through horizontal transmission. The presence of multidrug resistance and intra-hospital dissemination implicate C. striatum isolates as a potential target pathogen for infection control and antimicrobial stewardship programs.
| Original language | English |
|---|---|
| Pages (from-to) | 161-171 |
| Number of pages | 11 |
| Journal | Infection and Drug Resistance |
| Volume | 12 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- Corynebacterium striatum
- Multidrug resistant
- Multilocus sequence typing
- Nosocomial infections
- Opportunistic infections
ASJC Scopus subject areas
- Pharmacology
- Infectious Diseases
- Pharmacology (medical)
Cite this
Molecular epidemiology and clinical significance of corynebacterium striatum isolated from clinical specimens. / Suh, Jin Woong; Ju, Yongguk; Lee, Chang Kyu; Sohn, Jang Wook; Kim, Min Ja; Yoon, Young Kyung.
In: Infection and Drug Resistance, Vol. 12, 01.01.2019, p. 161-171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular epidemiology and clinical significance of corynebacterium striatum isolated from clinical specimens
AU - Suh, Jin Woong
AU - Ju, Yongguk
AU - Lee, Chang Kyu
AU - Sohn, Jang Wook
AU - Kim, Min Ja
AU - Yoon, Young Kyung
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: This study investigated the clinical epidemiology, antimicrobial susceptibility, and molecular epidemiology of Corynebacterium striatum isolates. Patients and methods: An observational study was conducted at a university hospital in the Republic of Korea from August to December 2016. All subjects were patients who tested positive for C. striatum clinically. Clinical data were analyzed to evaluate the microbiological and genotypic characteristics of C. striatum strains. Results: Sixty-seven C. striatum isolates recovered from non-duplicated patients were characterized. Patients were classified into three groups according to the infection type: nosocomial infection (71.6%), health care-associated infection (8.7%), and community-acquired infection (18.8%). The most common clinical specimens were urine (35.8%) and skin abscesses (32.8%). Fifty-two (77.6%) isolates showed multidrug resistance, defined as resistance to ≥3 different antibiotic families. All strains were susceptible to vancomycin and linezolid. Resistance to other antibiotics varied: penicillin (n=65; 97.0%), ampicillin (n=63; 94.0%), cefotaxime (n=64; 95.5%), and levofloxacin (n=61; 91.0%). Phylogenetic analysis identified all 16 S rRNA gene sequences of the 67 isolates as those of C. striatum, where 98%–99% were homologous to C. striatum ATCC 6940. In multilocus sequence typing for internal transcribed spacer region, gyrA, and rpoB sequencing, the most predominant sequence types (STs) were ST2, ST3, ST6, and ST5. Conclusion: C. striatum isolates may cause opportunistic infections associated with nosocomial infections through horizontal transmission. The presence of multidrug resistance and intra-hospital dissemination implicate C. striatum isolates as a potential target pathogen for infection control and antimicrobial stewardship programs.
AB - Purpose: This study investigated the clinical epidemiology, antimicrobial susceptibility, and molecular epidemiology of Corynebacterium striatum isolates. Patients and methods: An observational study was conducted at a university hospital in the Republic of Korea from August to December 2016. All subjects were patients who tested positive for C. striatum clinically. Clinical data were analyzed to evaluate the microbiological and genotypic characteristics of C. striatum strains. Results: Sixty-seven C. striatum isolates recovered from non-duplicated patients were characterized. Patients were classified into three groups according to the infection type: nosocomial infection (71.6%), health care-associated infection (8.7%), and community-acquired infection (18.8%). The most common clinical specimens were urine (35.8%) and skin abscesses (32.8%). Fifty-two (77.6%) isolates showed multidrug resistance, defined as resistance to ≥3 different antibiotic families. All strains were susceptible to vancomycin and linezolid. Resistance to other antibiotics varied: penicillin (n=65; 97.0%), ampicillin (n=63; 94.0%), cefotaxime (n=64; 95.5%), and levofloxacin (n=61; 91.0%). Phylogenetic analysis identified all 16 S rRNA gene sequences of the 67 isolates as those of C. striatum, where 98%–99% were homologous to C. striatum ATCC 6940. In multilocus sequence typing for internal transcribed spacer region, gyrA, and rpoB sequencing, the most predominant sequence types (STs) were ST2, ST3, ST6, and ST5. Conclusion: C. striatum isolates may cause opportunistic infections associated with nosocomial infections through horizontal transmission. The presence of multidrug resistance and intra-hospital dissemination implicate C. striatum isolates as a potential target pathogen for infection control and antimicrobial stewardship programs.
KW - Corynebacterium striatum
KW - Multidrug resistant
KW - Multilocus sequence typing
KW - Nosocomial infections
KW - Opportunistic infections
UR - http://www.scopus.com/inward/record.url?scp=85060601224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060601224&partnerID=8YFLogxK
U2 - 10.2147/IDR.S184518
DO - 10.2147/IDR.S184518
M3 - Article
AN - SCOPUS:85060601224
VL - 12
SP - 161
EP - 171
JO - Infection and Drug Resistance
JF - Infection and Drug Resistance
SN - 1178-6973
ER -