Molecular imaging with terahertz waves

Seung Jae Oh, Jihye Choi, Inhee Maeng, Jae Yeon Park, Kwangyeol Lee, Yong Min Huh, Jin Suck Suh, Seungjoo Haam, Joo Hiuk Son

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivo images of cancers. This technique can detect quantities of gold nanoparticles as small as 15 μM in vivo. A comparison of TMI images with near infrared absorption images shows the superior sensitivity of TMI. Furthermore, the quantification property of TMI is excellent, being linearly proportional to the concentration of nanoparticles. The target specificity issue is also addressed at the ex vivo and cell levels. The high thermal sensitivity of TMI can help extend photonic-based photothermal molecular imaging researches from the in vitro level to the in vivo level. The TMI technique can be used for monitoring drug delivery processes and for early cancer diagnosis.

Original languageEnglish
Pages (from-to)4009-4016
Number of pages8
JournalOptics Express
Volume19
Issue number5
DOIs
Publication statusPublished - 2011 Feb 28

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Oh, S. J., Choi, J., Maeng, I., Park, J. Y., Lee, K., Huh, Y. M., Suh, J. S., Haam, S., & Son, J. H. (2011). Molecular imaging with terahertz waves. Optics Express, 19(5), 4009-4016. https://doi.org/10.1364/OE.19.004009