Molecular linkage of hantavirus pulmonary syndrome to the white-fooled mouse, Peromyscus leucopus: Genetic characterization of the M genome of New York virus

B. Hjelle, S. W. Lee, W. Song, N. Torrez-Martinez, J. W. Song, R. Yanagihara, I. Gavrilovskaya, E. R. Mackow

Research output: Contribution to journalArticle

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Abstract

The complete M segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern United States and from white-footed mice, Peromyscus leucopus, from New York were 99% identical and differed from those of Four Corners virus by 23%. The serum of this patient failed to recognize a conserved, immunodominant epitope of the Four Corners virus G1 glycoprotein. Collectively, these findings indicate that P. leucopus harbors a genetically and antigenically distinct hantavirus that causes hantavirus pulmonary syndrome.

Original languageEnglish
Pages (from-to)8137-8141
Number of pages5
JournalJournal of virology
Volume69
Issue number12
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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