Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: Genetic characterization of the M genome of New York virus

Brian Hjelle, Shi Wu Lee, Wanmin Song, Norah Torrez-Martinez, Jin Won Song, Richard Yanagihara, Irina Gavrilovskaya, Erich R. Mackow

Research output: Contribution to journalArticle

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Abstract

The complete M segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern United States and from white-footed mice, Peromyscus leucopus, from New York were 99% identical and differed from those of Four Corners virus by 23%. The serum of this patient failed to recognize a conserved, immunodominant epitope of the Four Corners virus G1 glycoprotein. Collectively, these findings indicate that P. leucopus harbors a genetically and antigenically distinct hantavirus that causes hantavirus pulmonary syndrome.

Original languageEnglish
Pages (from-to)8137-8141
Number of pages5
JournalJournal of Virology
Volume69
Issue number12
Publication statusPublished - 1995 Dec 1
Externally publishedYes

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Sin Nombre virus
Hantavirus Pulmonary Syndrome
Peromyscus
Hantavirus
Genome
Viruses
Immunodominant Epitopes
New England
Glycoproteins
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus : Genetic characterization of the M genome of New York virus. / Hjelle, Brian; Lee, Shi Wu; Song, Wanmin; Torrez-Martinez, Norah; Song, Jin Won; Yanagihara, Richard; Gavrilovskaya, Irina; Mackow, Erich R.

In: Journal of Virology, Vol. 69, No. 12, 01.12.1995, p. 8137-8141.

Research output: Contribution to journalArticle

Hjelle, B, Lee, SW, Song, W, Torrez-Martinez, N, Song, JW, Yanagihara, R, Gavrilovskaya, I & Mackow, ER 1995, 'Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: Genetic characterization of the M genome of New York virus', Journal of Virology, vol. 69, no. 12, pp. 8137-8141.
Hjelle, Brian ; Lee, Shi Wu ; Song, Wanmin ; Torrez-Martinez, Norah ; Song, Jin Won ; Yanagihara, Richard ; Gavrilovskaya, Irina ; Mackow, Erich R. / Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus : Genetic characterization of the M genome of New York virus. In: Journal of Virology. 1995 ; Vol. 69, No. 12. pp. 8137-8141.
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