Molecular mechanism of inside-out integrin regulation

F. Ye, C. Kim, M. H. Ginsberg

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Integrins are cell surface adhesion and signaling receptors important for cell adhesion, survival and migration. Integrins are known to be regulated by signals from inside the cells. Such inside-out regulation modulates affinities of integrins for their extracellular matrix ligand and is critical for thrombosis, haemostasis and immune response. Talin and kindlin, two integrin binding proteins, have been shown to be important regulators of integrin function. In this review, we will focus on the molecular mechanism of integrin regulation that has emerged from recent structural, biochemical and genetic studies.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume9
Issue number1 S
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • Inside-out regulation
  • Integrin
  • Integrin activation
  • Kindlin
  • Talin

ASJC Scopus subject areas

  • Hematology

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