Molecular neurobiology and promising new treatment in depression

Sang Won Jeon, Yong Ku Kim

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The limited effects of currently available antidepressants are becoming an urgent issue in depression research. It takes a long time to determine treatment effects, and the overall remission rate is low. Although we expect the development of non-monoamine antidepressants in the near future, efforts in this regard over the past several decades have not yet been compensated. Thus, researchers and clinicians should clarify the neurobiological mechanisms of integrated modulators that regulate changes in genes, cells, the brain, and behaviors associated with depression. In this study, we review molecular neurobiological theories and new treatments for depression. Beyond neuroanatomy and monoamine theory, we discuss cells and molecules, neural plasticity, neurotrophisms, endocrine mechanisms, immunological mechanisms, genetics, circadian rhythms, and metabolic regulation in depression. In addition, we introduce the possibility of new antidepressant drug development using protein translation signaling (mTOR) pathways.

Original languageEnglish
Article number381
JournalInternational Journal of Molecular Sciences
Volume17
Issue number3
DOIs
Publication statusPublished - 2016 Mar 15

Keywords

  • Antidepressant
  • BDNF
  • Depression
  • Endocrine
  • Gene
  • Immune
  • MTOR
  • Neural plasticity
  • Neurobiology

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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