Molecular phenotyping small (Asian) versus large (Western) plaque psoriasis shows common activation of IL-17 pathway genes but different regulatory gene sets

Jaehwan Kim, Chil Hwan Oh, Jiehyun Jeon, Yoosang Baek, Jaewoo Ahn, Dong Joo Kim, Hyun Soo Lee, Joel Correa Da Rosa, Mayte Suárez-Fariñas, Michelle A. Lowes, James G. Krueger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian small and intermediate plaque psoriasis as psoriasis subtypes and compared their molecular signatures with the classic subtype of Western large plaque psoriasis. Two different characteristics of psoriatic spreading-vertical growth and radial expansion-were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared with Western large plaque psoriasis, Asian small plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated proinflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated proinflammatory cytokines were lower in Western large plaque psoriasis, whereas T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western large plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the disease subtype comparisons, we propose that dysregulation of T-cell expansion enabled by downregulation of immune negative regulators is the main mechanism for development of large plaque psoriasis subtypes.

Original languageEnglish
Pages (from-to)161-172
Number of pages12
JournalJournal of Investigative Dermatology
Volume136
Issue number1
DOIs
Publication statusPublished - 2016 Jan

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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    Kim, J., Oh, C. H., Jeon, J., Baek, Y., Ahn, J., Kim, D. J., Lee, H. S., Da Rosa, J. C., Suárez-Fariñas, M., Lowes, M. A., & Krueger, J. G. (2016). Molecular phenotyping small (Asian) versus large (Western) plaque psoriasis shows common activation of IL-17 pathway genes but different regulatory gene sets. Journal of Investigative Dermatology, 136(1), 161-172. https://doi.org/10.1038/JID.2015.378