Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam

Se Hun Gu, Burton K. Lim, Blaise Kadjo, Satoru Arai, Jeong Ah Kim, Violaine Nicolas, Aude Lalis, Christiane Denys, Joseph A. Cook, Samuel R. Dominguez, Kathryn V. Holmes, Lela Urushadze, Ketevan Sidamonidze, Davit Putkaradze, Ivan V. Kuzmin, Michael Y. Kosoy, Jin Won Song, Richard Yanagihara

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles prompted a further exploration of their host diversification by analyzing frozen, ethanol-fixed and RNAlater®-preserved archival tissues and fecal samples from 533 bats (representing seven families, 28 genera and 53 species in the order Chiroptera), captured in Asia, Africa and the Americas in 1981-2012, using RT-PCR. Hantavirus RNA was detected in Pomona roundleaf bats (Hipposideros pomona) (family Hipposideridae), captured in Vietnam in 1997 and 1999, and in banana pipistrelles (Neoromicia nanus) (family Vespertilionidae), captured in Côte d'Ivoire in 2011. Phylogenetic analysis, based on the full-length S- and partial M- and L-segment sequences using maximum likelihood and Bayesian methods, demonstrated that the newfound hantaviruses formed highly divergent lineages, comprising other recently recognized bat-borne hantaviruses in Sierra Leone and China. The detection of bat-associated hantaviruses opens a new era in hantavirology and provides insights into their evolutionary origins.

Original languageEnglish
Pages (from-to)1897-1910
Number of pages14
JournalViruses
Volume6
Issue number5
DOIs
Publication statusPublished - 2014 Apr 29

Keywords

  • Chiroptera
  • Evolution
  • Hantavirus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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    Gu, S. H., Lim, B. K., Kadjo, B., Arai, S., Kim, J. A., Nicolas, V., Lalis, A., Denys, C., Cook, J. A., Dominguez, S. R., Holmes, K. V., Urushadze, L., Sidamonidze, K., Putkaradze, D., Kuzmin, I. V., Kosoy, M. Y., Song, J. W., & Yanagihara, R. (2014). Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses, 6(5), 1897-1910. https://doi.org/10.3390/v6051897