@inproceedings{5f50f7f14fb44f0cbba796ed188167b0,
title = "Molecular sensing for biomarkers of invasive cancer cells using localized surface plasmon resonance",
abstract = "In this study, we describe the development of cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance (LSPR) that enabling recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of sensing chip was confirmed using various solvents that having different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto surface of GNRs and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from invasive cancer cells.",
keywords = "LSPR, MT1-MMP, biomarker, cancer, enzyme, molecular sensing, nanobiosensor, nanoparticle",
author = "Yoochan Hong and Minhee Ku and Suh, {Jin Suck} and Huh, {Yong Min} and Yoon, {Dae Sung} and Jaemoon Yang",
year = "2013",
doi = "10.1117/12.2018326",
language = "English",
isbn = "9780819493040",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Nano-Bio Sensing, Imaging, and Spectroscopy",
note = "SPIE Nano-Bio Sensing, Imaging, and Spectroscopy ; Conference date: 20-02-2013 Through 23-02-2013",
}
