Molecular testing of lymphoproliferative disorders: Current status and perspectives

The Hematopathology Study Group of the Korean Society of Pathologists, The Molecular Pathology Study Group of Korean Society of Pathologists

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cellof- origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

Original languageEnglish
Pages (from-to)224-241
Number of pages18
JournalJournal of Pathology and Translational Medicine
Volume51
Issue number3
DOIs
Publication statusPublished - 2017 May 1

Keywords

  • Clonality test
  • Fluorescence
  • Gene translocation
  • In situ hybridization
  • Lymphoproliferative disorders
  • Malignant lymphoma
  • Molecular
  • Molecular diagnostics
  • Next-generation sequencing
  • Pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    The Hematopathology Study Group of the Korean Society of Pathologists, & The Molecular Pathology Study Group of Korean Society of Pathologists (2017). Molecular testing of lymphoproliferative disorders: Current status and perspectives. Journal of Pathology and Translational Medicine, 51(3), 224-241. https://doi.org/10.4132/jptm.2017.04.09