Molecular testing of lymphoproliferative disorders: Current status and perspectives

The Hematopathology Study Group of the Korean Society of Pathologists, The Molecular Pathology Study Group of Korean Society of Pathologists

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)

    Abstract

    Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cellof- origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

    Original languageEnglish
    Pages (from-to)224-241
    Number of pages18
    JournalJournal of Pathology and Translational Medicine
    Volume51
    Issue number3
    DOIs
    Publication statusPublished - 2017 May 1

    Keywords

    • Clonality test
    • Fluorescence
    • Gene translocation
    • In situ hybridization
    • Lymphoproliferative disorders
    • Malignant lymphoma
    • Molecular
    • Molecular diagnostics
    • Next-generation sequencing
    • Pathology

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Histology

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