Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

Ji Hae Lee, Boram Cho, Hee jin Jun, Woo Duck Seo, Dong Woo Kim, Kang Jin Cho, Sung-Joon Lee

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6 Citations (Scopus)

Abstract

Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.

Original languageEnglish
Pages (from-to)805-812
Number of pages8
JournalBiotechnology Letters
Volume34
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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Keywords

  • Melanogenesis
  • Momilactone B
  • Protein kinase A
  • Tyrosinase

ASJC Scopus subject areas

  • Biotechnology

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