Monitoring of Blood Cytokines by PIT-1 Genotypes in Day 150 Male Pigs

J. Yoon, Min-Suk Rhee, D. S. Seo, Byoung-Chul Kim, Yong Ko

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Several studies have been done regarding carcass traits and growth in pigs. Recently, these have progressed to examine increases in economic traits, including meat quality and meat quantity, by using candidate genes. One of them is the pituitary-specific protein PIT-1, a member of the POU (Pit-Oct-Unc) family of transcription factors playing an important regulatory role in developmental processes. In addition, muscle development is known to be regulated in part by growth factors and cytokines locally produced. Therefore, studies were performed to analyze PIT-1 genotypes and serum cytokines (IGF-I, IGF-II, TGF-β1, EGF, cortisol, DHEA-S, IL-2, and IL-6) in castrated male pigs for their possible involvement in the development of carcass traits. The genotypes of PIT-1 gene were analyzed by PCR-RFLP with MspI restriction enzyme. But, only CD and DD genotypes, not CC genotype, have been detected. Based on PIT-1 genotyping, a significant difference in EGF expression beween CD type (78,8 ng/ml) and DD type (46.0 ng/ml) was detected (p<0.05), whereas other cytokines did not show any statistical significance depending on PIT-1 genotypes. Collectively, these results suggest the possibility that EGF could affect the formation of carcass traits. (Asian-Aust. J. Anim. Sci. 2001 Vol 14, No. 12 : 1659-1664).

Original languageEnglish
Pages (from-to)1659-1664
Number of pages6
JournalAsian-Australasian Journal of Animal Sciences
Volume14
Issue number12
Publication statusPublished - 2001 Dec 1

Fingerprint

cytokines
Swine
Genotype
Cytokines
swine
Epidermal Growth Factor
monitoring
genotype
carcass characteristics
blood
Meat
prasterone
insulin-like growth factor II
Insulin-Like Growth Factor II
Dehydroepiandrosterone
Muscle Development
muscle development
insulin-like growth factor I
interleukin-2
blood serum

Keywords

  • Cytokine
  • Growth Factor
  • Hormone
  • Pig
  • PIT-1

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Monitoring of Blood Cytokines by PIT-1 Genotypes in Day 150 Male Pigs. / Yoon, J.; Rhee, Min-Suk; Seo, D. S.; Kim, Byoung-Chul; Ko, Yong.

In: Asian-Australasian Journal of Animal Sciences, Vol. 14, No. 12, 01.12.2001, p. 1659-1664.

Research output: Contribution to journalArticle

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