Abstract
Several studies have been done regarding carcass traits and growth in pigs. Recently, these have progressed to examine increases in economic traits, including meat quality and meat quantity, by using candidate genes. One of them is the pituitary-specific protein PIT-1, a member of the POU (Pit-Oct-Unc) family of transcription factors playing an important regulatory role in developmental processes. In addition, muscle development is known to be regulated in part by growth factors and cytokines locally produced. Therefore, studies were performed to analyze PIT-1 genotypes and serum cytokines (IGF-I, IGF-II, TGF-β1, EGF, cortisol, DHEA-S, IL-2, and IL-6) in castrated male pigs for their possible involvement in the development of carcass traits. The genotypes of PIT-1 gene were analyzed by PCR-RFLP with MspI restriction enzyme. But, only CD and DD genotypes, not CC genotype, have been detected. Based on PIT-1 genotyping, a significant difference in EGF expression beween CD type (78,8 ng/ml) and DD type (46.0 ng/ml) was detected (p<0.05), whereas other cytokines did not show any statistical significance depending on PIT-1 genotypes. Collectively, these results suggest the possibility that EGF could affect the formation of carcass traits. (Asian-Aust. J. Anim. Sci. 2001 Vol 14, No. 12 : 1659-1664).
| Original language | English |
|---|---|
| Pages (from-to) | 1659-1664 |
| Number of pages | 6 |
| Journal | Asian-Australasian Journal of Animal Sciences |
| Volume | 14 |
| Issue number | 12 |
| Publication status | Published - 2001 Dec 1 |
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Keywords
- Cytokine
- Growth Factor
- Hormone
- Pig
- PIT-1
ASJC Scopus subject areas
- Animal Science and Zoology
Cite this
Monitoring of Blood Cytokines by PIT-1 Genotypes in Day 150 Male Pigs. / Yoon, J.; Rhee, Min-Suk; Seo, D. S.; Kim, Byoung-Chul; Ko, Yong.
In: Asian-Australasian Journal of Animal Sciences, Vol. 14, No. 12, 01.12.2001, p. 1659-1664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monitoring of Blood Cytokines by PIT-1 Genotypes in Day 150 Male Pigs
AU - Yoon, J.
AU - Rhee, Min-Suk
AU - Seo, D. S.
AU - Kim, Byoung-Chul
AU - Ko, Yong
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Several studies have been done regarding carcass traits and growth in pigs. Recently, these have progressed to examine increases in economic traits, including meat quality and meat quantity, by using candidate genes. One of them is the pituitary-specific protein PIT-1, a member of the POU (Pit-Oct-Unc) family of transcription factors playing an important regulatory role in developmental processes. In addition, muscle development is known to be regulated in part by growth factors and cytokines locally produced. Therefore, studies were performed to analyze PIT-1 genotypes and serum cytokines (IGF-I, IGF-II, TGF-β1, EGF, cortisol, DHEA-S, IL-2, and IL-6) in castrated male pigs for their possible involvement in the development of carcass traits. The genotypes of PIT-1 gene were analyzed by PCR-RFLP with MspI restriction enzyme. But, only CD and DD genotypes, not CC genotype, have been detected. Based on PIT-1 genotyping, a significant difference in EGF expression beween CD type (78,8 ng/ml) and DD type (46.0 ng/ml) was detected (p<0.05), whereas other cytokines did not show any statistical significance depending on PIT-1 genotypes. Collectively, these results suggest the possibility that EGF could affect the formation of carcass traits. (Asian-Aust. J. Anim. Sci. 2001 Vol 14, No. 12 : 1659-1664).
AB - Several studies have been done regarding carcass traits and growth in pigs. Recently, these have progressed to examine increases in economic traits, including meat quality and meat quantity, by using candidate genes. One of them is the pituitary-specific protein PIT-1, a member of the POU (Pit-Oct-Unc) family of transcription factors playing an important regulatory role in developmental processes. In addition, muscle development is known to be regulated in part by growth factors and cytokines locally produced. Therefore, studies were performed to analyze PIT-1 genotypes and serum cytokines (IGF-I, IGF-II, TGF-β1, EGF, cortisol, DHEA-S, IL-2, and IL-6) in castrated male pigs for their possible involvement in the development of carcass traits. The genotypes of PIT-1 gene were analyzed by PCR-RFLP with MspI restriction enzyme. But, only CD and DD genotypes, not CC genotype, have been detected. Based on PIT-1 genotyping, a significant difference in EGF expression beween CD type (78,8 ng/ml) and DD type (46.0 ng/ml) was detected (p<0.05), whereas other cytokines did not show any statistical significance depending on PIT-1 genotypes. Collectively, these results suggest the possibility that EGF could affect the formation of carcass traits. (Asian-Aust. J. Anim. Sci. 2001 Vol 14, No. 12 : 1659-1664).
KW - Cytokine
KW - Growth Factor
KW - Hormone
KW - Pig
KW - PIT-1
UR - http://www.scopus.com/inward/record.url?scp=0035634943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035634943&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0035634943
VL - 14
SP - 1659
EP - 1664
JO - Asian-Australasian Journal of Animal Sciences
JF - Asian-Australasian Journal of Animal Sciences
SN - 1011-2367
IS - 12
ER -