Monitoring of swelling and degrading behavior of alginate beads using optical tweezers

Lan Jin, You Chan Hong, Jin Woo Pyo, Hanwook Song, Ji Yoon Kang, Sang Woo Lee, Dae Sung Yoon, Beop-Min Kim, Kwangsoo No

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calcium alginate beads are widely used in drug delivery studies due to their high biocompatibility and the simple gelatinization process. It is well known that the alginate bead size changes in solutions with time, increasing initially and decreasing at a later stage. Therefore, it is essential to monitor or predict the size change of the beads since it affects the drug delivery efficiency significantly. We used the optical tweezers, a non-contact method, to investigate the temporal changes of the alginate beads in solutions instead of using the traditional drying and weighing technique. Responses to alginate concentration or external stimuli such as pH were also studied. The power spectrum method was utilized to estimate the trapping forces on the beads, which is related to the particle size changes. The results of our experiment indicate that the optical tweezers technique can continuously monitor the swelling and degrading of an alginate bead in an aqueous medium over hours which poses a high potential for drug encapsulation and release efficiency studies in the future.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalBiochip Journal
Volume3
Issue number3
Publication statusPublished - 2009 Oct 28

Fingerprint

Optical Tweezers
Optical tweezers
Alginate
Swelling
Monitoring
Drug delivery
Weighing
Power spectrum
Biocompatibility
Encapsulation
Particle Size
Pharmaceutical Preparations
Calcium
Drying
Particle size
alginic acid
Experiments

Keywords

  • Alginate bead
  • Degradation
  • Optical tweezers
  • Power spectral density
  • Swelling

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Jin, L., Hong, Y. C., Pyo, J. W., Song, H., Kang, J. Y., Lee, S. W., ... No, K. (2009). Monitoring of swelling and degrading behavior of alginate beads using optical tweezers. Biochip Journal, 3(3), 213-218.

Monitoring of swelling and degrading behavior of alginate beads using optical tweezers. / Jin, Lan; Hong, You Chan; Pyo, Jin Woo; Song, Hanwook; Kang, Ji Yoon; Lee, Sang Woo; Yoon, Dae Sung; Kim, Beop-Min; No, Kwangsoo.

In: Biochip Journal, Vol. 3, No. 3, 28.10.2009, p. 213-218.

Research output: Contribution to journalArticle

Jin, L, Hong, YC, Pyo, JW, Song, H, Kang, JY, Lee, SW, Yoon, DS, Kim, B-M & No, K 2009, 'Monitoring of swelling and degrading behavior of alginate beads using optical tweezers', Biochip Journal, vol. 3, no. 3, pp. 213-218.
Jin L, Hong YC, Pyo JW, Song H, Kang JY, Lee SW et al. Monitoring of swelling and degrading behavior of alginate beads using optical tweezers. Biochip Journal. 2009 Oct 28;3(3):213-218.
Jin, Lan ; Hong, You Chan ; Pyo, Jin Woo ; Song, Hanwook ; Kang, Ji Yoon ; Lee, Sang Woo ; Yoon, Dae Sung ; Kim, Beop-Min ; No, Kwangsoo. / Monitoring of swelling and degrading behavior of alginate beads using optical tweezers. In: Biochip Journal. 2009 ; Vol. 3, No. 3. pp. 213-218.
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