Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Won Young Kim, Miae Won, Abbas Salimi, Amit Sharma, Jong Hyeon Lim, Seung Hae Kwon, Joo Yeong Jeon, Jin Yong Lee, Jong Seung Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Original languageEnglish
Pages (from-to)13267-13270
Number of pages4
JournalChemical Communications
Volume55
Issue number88
DOIs
Publication statusPublished - 2019 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Kim, W. Y., Won, M., Salimi, A., Sharma, A., Lim, J. H., Kwon, S. H., Jeon, J. Y., Lee, J. Y., & Kim, J. S. (2019). Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis. Chemical Communications, 55(88), 13267-13270. https://doi.org/10.1039/c9cc07009e