Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hwa Jeong Seon, Hye Hwang Ji, Hee Lee Min, Koo Lee Myung, Dongho Lee, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

Original languageEnglish
Pages (from-to)1324-1327
Number of pages4
JournalArchives of pharmacal research
Volume28
Issue number12
Publication statusPublished - 2005 Dec
Externally publishedYes

Keywords

  • Cudrania tricuspidata
  • Gancaonin A
  • Monoamine oxidase inhibitor
  • Moraceae
  • Prenylated isoflavone

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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