Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hwa Jeong Seon, Hye Hwang Ji, Hee Lee Min, Koo Lee Myung, Dongho Lee, Seup R. Jai, Yeon Hwang Bang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

Original languageEnglish
Pages (from-to)1324-1327
Number of pages4
JournalArchives of Pharmacal Research
Volume28
Issue number12
Publication statusPublished - 2005 Dec 1
Externally publishedYes

Fingerprint

Moraceae
Monoamine Oxidase
Fruits
Fruit
Inhibitory Concentration 50
Isoflavones
Methylene Chloride
Fractionation
Brain
Kinetics
gancaonin A

Keywords

  • Cudrania tricuspidata
  • Gancaonin A
  • Monoamine oxidase inhibitor
  • Moraceae
  • Prenylated isoflavone

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Xiang, H. H., Seong, S. H., Ji, S. H., Seon, H. J., Ji, H. H., Min, H. L., ... Bang, Y. H. (2005). Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata. Archives of Pharmacal Research, 28(12), 1324-1327.

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata. / Xiang, Hua Han; Seong, Su Hong; Ji, Sang Hwang; Seon, Hwa Jeong; Ji, Hye Hwang; Min, Hee Lee; Myung, Koo Lee; Lee, Dongho; Jai, Seup R.; Bang, Yeon Hwang.

In: Archives of Pharmacal Research, Vol. 28, No. 12, 01.12.2005, p. 1324-1327.

Research output: Contribution to journalArticle

Xiang, HH, Seong, SH, Ji, SH, Seon, HJ, Ji, HH, Min, HL, Myung, KL, Lee, D, Jai, SR & Bang, YH 2005, 'Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata', Archives of Pharmacal Research, vol. 28, no. 12, pp. 1324-1327.
Xiang HH, Seong SH, Ji SH, Seon HJ, Ji HH, Min HL et al. Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata. Archives of Pharmacal Research. 2005 Dec 1;28(12):1324-1327.
Xiang, Hua Han ; Seong, Su Hong ; Ji, Sang Hwang ; Seon, Hwa Jeong ; Ji, Hye Hwang ; Min, Hee Lee ; Myung, Koo Lee ; Lee, Dongho ; Jai, Seup R. ; Bang, Yeon Hwang. / Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata. In: Archives of Pharmacal Research. 2005 ; Vol. 28, No. 12. pp. 1324-1327.
@article{b6ca8217bf504449bf0b858114576a83,
title = "Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata",
abstract = "A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.",
keywords = "Cudrania tricuspidata, Gancaonin A, Monoamine oxidase inhibitor, Moraceae, Prenylated isoflavone",
author = "Xiang, {Hua Han} and Seong, {Su Hong} and Ji, {Sang Hwang} and Seon, {Hwa Jeong} and Ji, {Hye Hwang} and Min, {Hee Lee} and Myung, {Koo Lee} and Dongho Lee and Jai, {Seup R.} and Bang, {Yeon Hwang}",
year = "2005",
month = "12",
day = "1",
language = "English",
volume = "28",
pages = "1324--1327",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "12",

}

TY - JOUR

T1 - Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

AU - Xiang, Hua Han

AU - Seong, Su Hong

AU - Ji, Sang Hwang

AU - Seon, Hwa Jeong

AU - Ji, Hye Hwang

AU - Min, Hee Lee

AU - Myung, Koo Lee

AU - Lee, Dongho

AU - Jai, Seup R.

AU - Bang, Yeon Hwang

PY - 2005/12/1

Y1 - 2005/12/1

N2 - A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

AB - A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

KW - Cudrania tricuspidata

KW - Gancaonin A

KW - Monoamine oxidase inhibitor

KW - Moraceae

KW - Prenylated isoflavone

UR - http://www.scopus.com/inward/record.url?scp=29944447056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29944447056&partnerID=8YFLogxK

M3 - Article

C2 - 16392662

AN - SCOPUS:29944447056

VL - 28

SP - 1324

EP - 1327

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 12

ER -