Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus

Hwa Jeong Seon, Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hye Hwang Ji, Dongho Lee, Koo Lee Myung, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalArchives of pharmacal research
Volume29
Issue number12
DOIs
Publication statusPublished - 2006 Dec 31

Keywords

  • Coumarin
  • Dictamnus albus
  • Monoamine oxidase inhibitor
  • Rutaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Seon, H. J., Xiang, H. H., Seong, S. H., Ji, S. H., Ji, H. H., Lee, D., Myung, K. L., Jai, S. R., & Bang, Y. H. (2006). Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus. Archives of pharmacal research, 29(12), 1119-1124. https://doi.org/10.1007/bf02969302