Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

Xiang Hua Han, Ji Hye Hwang, Seong Su Hong, Sanggil Choe, Chul Lee, Moon Soon Lee, Dongho Lee, Myung Koo Lee, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalNatural Product Sciences
Volume16
Issue number2
Publication statusPublished - 2010 Jun

Keywords

  • Benzylated flavonoid
  • Cudrania tricuspidata
  • Monoamine oxidase inhibitor
  • Moraceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Han, X. H., Hwang, J. H., Hong, S. S., Choe, S., Lee, C., Lee, M. S., Lee, D., Lee, M. K., Lee, M. K., & Hwang, B. Y. (2010). Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata. Natural Product Sciences, 16(2), 75-79.