Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

Xiang Hua Han, Ji Hye Hwang, Seong Su Hong, Sanggil Choe, Chul Lee, Moon Soon Lee, Dongho Lee, Myung Koo Lee, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalNatural Product Sciences
Volume16
Issue number2
Publication statusPublished - 2010 Jun 1

Fingerprint

Moraceae
Monoamine Oxidase
Flavonoids
Inhibitory Concentration 50
Nuclear magnetic resonance
artocarpesin
kaempferol

Keywords

  • Benzylated flavonoid
  • Cudrania tricuspidata
  • Monoamine oxidase inhibitor
  • Moraceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

Cite this

Han, X. H., Hwang, J. H., Hong, S. S., Choe, S., Lee, C., Lee, M. S., ... Hwang, B. Y. (2010). Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata. Natural Product Sciences, 16(2), 75-79.

Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata. / Han, Xiang Hua; Hwang, Ji Hye; Hong, Seong Su; Choe, Sanggil; Lee, Chul; Lee, Moon Soon; Lee, Dongho; Lee, Myung Koo; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Natural Product Sciences, Vol. 16, No. 2, 01.06.2010, p. 75-79.

Research output: Contribution to journalArticle

Han, XH, Hwang, JH, Hong, SS, Choe, S, Lee, C, Lee, MS, Lee, D, Lee, MK, Lee, MK & Hwang, BY 2010, 'Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata', Natural Product Sciences, vol. 16, no. 2, pp. 75-79.
Han XH, Hwang JH, Hong SS, Choe S, Lee C, Lee MS et al. Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata. Natural Product Sciences. 2010 Jun 1;16(2):75-79.
Han, Xiang Hua ; Hwang, Ji Hye ; Hong, Seong Su ; Choe, Sanggil ; Lee, Chul ; Lee, Moon Soon ; Lee, Dongho ; Lee, Myung Koo ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata. In: Natural Product Sciences. 2010 ; Vol. 16, No. 2. pp. 75-79.
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