Monocyte transplantation for neural and cardiovascular ischemia repair

Paul R. Sanberg, Dong Hyuk Park, Nicole Kuzmin-Nichols, Eduardo Cruz, Nelson Americo Hossne, Enio Buffolo, Alison E. Willing

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Neovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. In terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. In addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their pro-angiogenic ability. In this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.

    Original languageEnglish
    Pages (from-to)553-563
    Number of pages11
    JournalJournal of Cellular and Molecular Medicine
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - 2010 Mar

    Keywords

    • Angiogenesis/arteriogenesis
    • Bone marrow
    • Inflammation
    • Ischemia
    • Monocyte/macrophage
    • Peripheral blood
    • Stem cells
    • Transplantation
    • Umbilical cord blood

    ASJC Scopus subject areas

    • Molecular Medicine
    • Cell Biology

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