Monocyte transplantation for neural and cardiovascular ischemia repair

Paul R. Sanberg, Dong Hyuk Park, Nicole Kuzmin-Nichols, Eduardo Cruz, Nelson Americo Hossne, Enio Buffolo, Alison E. Willing

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Neovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. In terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. In addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their pro-angiogenic ability. In this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.

Original languageEnglish
Pages (from-to)553-563
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume14
Issue number3
DOIs
Publication statusPublished - 2010 Mar

Keywords

  • Angiogenesis/arteriogenesis
  • Bone marrow
  • Inflammation
  • Ischemia
  • Monocyte/macrophage
  • Peripheral blood
  • Stem cells
  • Transplantation
  • Umbilical cord blood

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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  • Cite this

    Sanberg, P. R., Park, D. H., Kuzmin-Nichols, N., Cruz, E., Hossne, N. A., Buffolo, E., & Willing, A. E. (2010). Monocyte transplantation for neural and cardiovascular ischemia repair. Journal of Cellular and Molecular Medicine, 14(3), 553-563. https://doi.org/10.1111/j.1582-4934.2009.00903.x