Monocytic, Th1 and Th2 cytokine alterations in the pathophysiology of schizophrenia

Kyeong Sae Na, Yong Ku Kim

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A growing body of evidence suggests that changes in the serum levels and cellular production of various cytokines are associated with the immunological abnormalities of schizophrenia. Several studies have examined alterations in T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in schizophrenia. We explored monocytic, Th1 and Th2 cytokines in 43 schizophrenia patients and 50 normal controls. The mitogen-induced production of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-4, γ-interferon (IFN-γ) and IL-2 was measured with enzyme-linked immunosorbent assays before and after antipsychotic treatment. IL-6 and TNF-α production by schizophrenic patients was significantly higher than by normal controls, while IL-2, IL-4 and IFN-γ production was significantly lower in schizophrenic patients. After 6 weeks of antipsychotic treatment, IL-6 and TNF-α production was significantly decreased, while IL-4, IFN-γ and IL-2 productions were not significantly changed. Our results suggest that increased monocytic cytokines and decreased Th1 and Th2 cytokines may be associated with the immunopathogenesis of acute psychotic schizophrenia, and that antipsychotics may play an important role in immune response by decreasing elevated monocytic cytokines.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalNeuropsychobiology
Volume56
Issue number2-3
DOIs
Publication statusPublished - 2008 Feb 1

Fingerprint

Schizophrenia
Cytokines
Interleukin-4
Antipsychotic Agents
Interleukin-2
Interleukin-6
Tumor Necrosis Factor-alpha
Mitogens
Interferons
Enzyme-Linked Immunosorbent Assay
Therapeutics
Serum

Keywords

  • Antipsychotics
  • Cytokines
  • Interferons
  • Interleukins
  • Psychoimmunology
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Monocytic, Th1 and Th2 cytokine alterations in the pathophysiology of schizophrenia. / Na, Kyeong Sae; Kim, Yong Ku.

In: Neuropsychobiology, Vol. 56, No. 2-3, 01.02.2008, p. 55-63.

Research output: Contribution to journalArticle

@article{31190e5d37a745338836cd9f7e78c7bf,
title = "Monocytic, Th1 and Th2 cytokine alterations in the pathophysiology of schizophrenia",
abstract = "A growing body of evidence suggests that changes in the serum levels and cellular production of various cytokines are associated with the immunological abnormalities of schizophrenia. Several studies have examined alterations in T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in schizophrenia. We explored monocytic, Th1 and Th2 cytokines in 43 schizophrenia patients and 50 normal controls. The mitogen-induced production of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-4, γ-interferon (IFN-γ) and IL-2 was measured with enzyme-linked immunosorbent assays before and after antipsychotic treatment. IL-6 and TNF-α production by schizophrenic patients was significantly higher than by normal controls, while IL-2, IL-4 and IFN-γ production was significantly lower in schizophrenic patients. After 6 weeks of antipsychotic treatment, IL-6 and TNF-α production was significantly decreased, while IL-4, IFN-γ and IL-2 productions were not significantly changed. Our results suggest that increased monocytic cytokines and decreased Th1 and Th2 cytokines may be associated with the immunopathogenesis of acute psychotic schizophrenia, and that antipsychotics may play an important role in immune response by decreasing elevated monocytic cytokines.",
keywords = "Antipsychotics, Cytokines, Interferons, Interleukins, Psychoimmunology, Schizophrenia",
author = "Na, {Kyeong Sae} and Kim, {Yong Ku}",
year = "2008",
month = "2",
day = "1",
doi = "10.1159/000111535",
language = "English",
volume = "56",
pages = "55--63",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "2-3",

}

TY - JOUR

T1 - Monocytic, Th1 and Th2 cytokine alterations in the pathophysiology of schizophrenia

AU - Na, Kyeong Sae

AU - Kim, Yong Ku

PY - 2008/2/1

Y1 - 2008/2/1

N2 - A growing body of evidence suggests that changes in the serum levels and cellular production of various cytokines are associated with the immunological abnormalities of schizophrenia. Several studies have examined alterations in T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in schizophrenia. We explored monocytic, Th1 and Th2 cytokines in 43 schizophrenia patients and 50 normal controls. The mitogen-induced production of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-4, γ-interferon (IFN-γ) and IL-2 was measured with enzyme-linked immunosorbent assays before and after antipsychotic treatment. IL-6 and TNF-α production by schizophrenic patients was significantly higher than by normal controls, while IL-2, IL-4 and IFN-γ production was significantly lower in schizophrenic patients. After 6 weeks of antipsychotic treatment, IL-6 and TNF-α production was significantly decreased, while IL-4, IFN-γ and IL-2 productions were not significantly changed. Our results suggest that increased monocytic cytokines and decreased Th1 and Th2 cytokines may be associated with the immunopathogenesis of acute psychotic schizophrenia, and that antipsychotics may play an important role in immune response by decreasing elevated monocytic cytokines.

AB - A growing body of evidence suggests that changes in the serum levels and cellular production of various cytokines are associated with the immunological abnormalities of schizophrenia. Several studies have examined alterations in T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in schizophrenia. We explored monocytic, Th1 and Th2 cytokines in 43 schizophrenia patients and 50 normal controls. The mitogen-induced production of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-4, γ-interferon (IFN-γ) and IL-2 was measured with enzyme-linked immunosorbent assays before and after antipsychotic treatment. IL-6 and TNF-α production by schizophrenic patients was significantly higher than by normal controls, while IL-2, IL-4 and IFN-γ production was significantly lower in schizophrenic patients. After 6 weeks of antipsychotic treatment, IL-6 and TNF-α production was significantly decreased, while IL-4, IFN-γ and IL-2 productions were not significantly changed. Our results suggest that increased monocytic cytokines and decreased Th1 and Th2 cytokines may be associated with the immunopathogenesis of acute psychotic schizophrenia, and that antipsychotics may play an important role in immune response by decreasing elevated monocytic cytokines.

KW - Antipsychotics

KW - Cytokines

KW - Interferons

KW - Interleukins

KW - Psychoimmunology

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=40349111658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349111658&partnerID=8YFLogxK

U2 - 10.1159/000111535

DO - 10.1159/000111535

M3 - Article

C2 - 18037815

AN - SCOPUS:40349111658

VL - 56

SP - 55

EP - 63

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 2-3

ER -