Morphologic changes in trabecular meshwork after patterned and argon laser trabeculoplasty in cats

Jong Yeon Lee, Seung Yeon Ha, Hae Jung Paik, Kun Young Kwon, Yong Yeon Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Patterned laser trabeculoplasty (PLT) was introduced as it claimed to cause less thermal damage and provide more uniform coverage of the trabecular meshwork than argon laser trabeculoplasty (ALT). The objective of this study was to investigate morphologic changes in the trabecular meshwork after PLT or ALT in cats. Materials and Methods: We performed ALT in the right eyes and PLT in the left eyes of 6 domestic cats. A seventh cat was assigned as a control. Two ranges of laser energy were used for PLT: supra-threshold energy of 400-450mW in 3 cats and sub-threshold energy of 250 to 350mW in 3 cats. Specimens were obtained at 1, 4 and 9 weeks after treatment. Structural changes in the trabecular meshwork were evaluated by light microscopy and scanning electron microscopy. Results: The trabecular meshwork after supra-threshold PLT revealed coagulative damage such as a crater-like lesion with disruption of trabecular beams in early period and extensive membranous obliteration in the late period (at 4 and 9 weeks after treatment), which were comparable to tissue changes after ALT. Sub-threshold PLT resulted in thinning of the uveal meshwork and denudation of trabecular endothelial cells whereas it did not disrupt trabecular beams. Nevertheless, following sub-threshold PLT, partial membranous coverages were observed in the trabecular meshwork in the late period. Conclusions: When used at sub-threshold power, PLT caused less thermal damage to the trabecular meshwork than ALT. However, it did not effectively prevent late scarring of the trabecular meshwork in cats.

Original languageEnglish
Pages (from-to)908-916
Number of pages9
JournalCurrent Eye Research
Volume39
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Trabecular Meshwork
Trabeculectomy
Argon
Cats
Lasers
Hot Temperature
Electron Scanning Microscopy

Keywords

  • Cat
  • Glaucoma
  • laser trabeculoplasty
  • Scanning electron microscopy
  • Trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Morphologic changes in trabecular meshwork after patterned and argon laser trabeculoplasty in cats. / Lee, Jong Yeon; Ha, Seung Yeon; Paik, Hae Jung; Kwon, Kun Young; Kim, Yong Yeon.

In: Current Eye Research, Vol. 39, No. 9, 01.01.2014, p. 908-916.

Research output: Contribution to journalArticle

Lee, Jong Yeon ; Ha, Seung Yeon ; Paik, Hae Jung ; Kwon, Kun Young ; Kim, Yong Yeon. / Morphologic changes in trabecular meshwork after patterned and argon laser trabeculoplasty in cats. In: Current Eye Research. 2014 ; Vol. 39, No. 9. pp. 908-916.
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abstract = "Purpose: Patterned laser trabeculoplasty (PLT) was introduced as it claimed to cause less thermal damage and provide more uniform coverage of the trabecular meshwork than argon laser trabeculoplasty (ALT). The objective of this study was to investigate morphologic changes in the trabecular meshwork after PLT or ALT in cats. Materials and Methods: We performed ALT in the right eyes and PLT in the left eyes of 6 domestic cats. A seventh cat was assigned as a control. Two ranges of laser energy were used for PLT: supra-threshold energy of 400-450mW in 3 cats and sub-threshold energy of 250 to 350mW in 3 cats. Specimens were obtained at 1, 4 and 9 weeks after treatment. Structural changes in the trabecular meshwork were evaluated by light microscopy and scanning electron microscopy. Results: The trabecular meshwork after supra-threshold PLT revealed coagulative damage such as a crater-like lesion with disruption of trabecular beams in early period and extensive membranous obliteration in the late period (at 4 and 9 weeks after treatment), which were comparable to tissue changes after ALT. Sub-threshold PLT resulted in thinning of the uveal meshwork and denudation of trabecular endothelial cells whereas it did not disrupt trabecular beams. Nevertheless, following sub-threshold PLT, partial membranous coverages were observed in the trabecular meshwork in the late period. Conclusions: When used at sub-threshold power, PLT caused less thermal damage to the trabecular meshwork than ALT. However, it did not effectively prevent late scarring of the trabecular meshwork in cats.",
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