TY - JOUR
T1 - MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS
AU - Jang, Sungmin
AU - Park, Seo Yeon
AU - Ahn, So Min
AU - Hwang, Soon Young
AU - Kim, Seong Woo
AU - Oh, Jaeryung
AU - Yun, Cheolmin
N1 - Funding Information:
Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033092).
Publisher Copyright:
Copyright © by Ophthalmic Communications Society, Inc
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.
AB - Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.
KW - Early age-related macular degeneration
KW - Optical coherence tomography
KW - Optical coherence tomography angiography
KW - Retinal pigment epithelium
KW - Subretinal drusenoid deposits
UR - http://www.scopus.com/inward/record.url?scp=85082561072&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000002528
DO - 10.1097/IAE.0000000000002528
M3 - Article
C2 - 30950969
AN - SCOPUS:85082561072
VL - 40
SP - 686
EP - 694
JO - Retina
JF - Retina
SN - 0275-004X
IS - 4
ER -