MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS

Sungmin Jang, Seo Yeon Park, So Min Ahn, Soon Young Hwang, Seong Woo Kim, Jaeryung Oh, Cheolmin Yun

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    Abstract

    Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.

    Original languageEnglish
    Pages (from-to)686-694
    Number of pages9
    JournalRetina
    Volume40
    Issue number4
    DOIs
    Publication statusPublished - 2020 Apr 1

    Keywords

    • Early age-related macular degeneration
    • Optical coherence tomography
    • Optical coherence tomography angiography
    • Retinal pigment epithelium
    • Subretinal drusenoid deposits

    ASJC Scopus subject areas

    • Ophthalmology

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