Morphological changes in dendritic spines of Purkinje cells associated with motor learning

Kea Joo Lee, Joon Goo Jung, Tatsuo Arii, Keiji Imoto, Im Joo Rhyu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Experience-dependent changes of spine structure and number may contribute to long-term memory storage. Although several studies demonstrated structural spine plasticity following associative learning, there is limited evidence associating motor learning with alteration of spine morphology. Here, we investigated this issue in the cerebellar Purkinje cells using high voltage electron microscopy (HVEM). Adult rats were trained in an obstacle course, demanding significant motor coordination to complete. Control animals either traversed an obstacle-free runway or remained sedentary. Quantitative analysis of spine morphology showed that the density and length of dendritic spines along the distal dendrites of Purkinje cells were significantly increased in the rats that learned complex motor skills compared to active or inactive controls. Classification of spines into shape categories indicated that the increased spine density and length after motor learning was mainly attributable to an increase in thin spines. These findings suggest that motor learning induces structural spine plasticity in the cerebellar Purkinje neurons, which may play a crucial role in acquiring complex motor skills.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalNeurobiology of Learning and Memory
Volume88
Issue number4
DOIs
Publication statusPublished - 2007 Nov 1

Fingerprint

Dendritic Spines
Purkinje Cells
Spine
Learning
Motor Skills
Long-Term Memory
Dendrites
Electron Microscopy

Keywords

  • Cerebellum
  • HVEM
  • Learning
  • Motor coordination
  • Spine shape
  • Synaptic plasticity

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Morphological changes in dendritic spines of Purkinje cells associated with motor learning. / Lee, Kea Joo; Jung, Joon Goo; Arii, Tatsuo; Imoto, Keiji; Rhyu, Im Joo.

In: Neurobiology of Learning and Memory, Vol. 88, No. 4, 01.11.2007, p. 445-450.

Research output: Contribution to journalArticle

Lee, Kea Joo ; Jung, Joon Goo ; Arii, Tatsuo ; Imoto, Keiji ; Rhyu, Im Joo. / Morphological changes in dendritic spines of Purkinje cells associated with motor learning. In: Neurobiology of Learning and Memory. 2007 ; Vol. 88, No. 4. pp. 445-450.
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