Morphometric assessment of nuclei in Bowen's disease and bowenoid papulosis

Dong Soo Yu, Gina Kim, Hae Jun Song, Chil Hwan Oh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Occasionally, Bowen's disease and bowenoid papulosis cannot be distinguished in microscopic finding. Their clinical presentations are quite different from one another. The purpose of this study was to evaluate the histological differences in Bowen's disease and bowenoid papulosis, by comparing the size and shape of nuclei, using image analysis system. Methods: We performed morphometric assessment on 13 specimens of Bowen's disease and eight specimens of bowenoid papulosis using an image analysis system, and the following parameters were calculated, such as nuclear contour index (NCI), irregularities of nucleus (IN), form factor (form AR) and circulatory factor (form PE). Results: For NCI, there were significant differences between the Bowen's disease and bowenoid papulosis, and IN also shows significant differences between these two diseases, showing that Bowen's disease has more corrugated or indented nucleus contour than bowenoid papulosis. In the parameter of form PE, there were significant differences between the two diseases, indicating that Bowen's disease has more oval-shaped nuclei than bowenoid papulosis. There were no significant differences in form factor between Bowen's disease and bowenoid pupulosis. Conclusions: Significant differences were found in the morphometric evaluation between Bowen's disease and bowenoid papulosis. The nuclei were larger, more oval and more irregular margins in Bowen's disease than bowenoid papulosis.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalSkin Research and Technology
Volume10
Issue number1
DOIs
Publication statusPublished - 2004 Feb 1

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Bowen's Disease

Keywords

  • Bowen's disease
  • Bowenoid papulosis
  • Morphometric assessment

ASJC Scopus subject areas

  • Dermatology

Cite this

Morphometric assessment of nuclei in Bowen's disease and bowenoid papulosis. / Yu, Dong Soo; Kim, Gina; Song, Hae Jun; Oh, Chil Hwan.

In: Skin Research and Technology, Vol. 10, No. 1, 01.02.2004, p. 67-70.

Research output: Contribution to journalArticle

Yu, Dong Soo ; Kim, Gina ; Song, Hae Jun ; Oh, Chil Hwan. / Morphometric assessment of nuclei in Bowen's disease and bowenoid papulosis. In: Skin Research and Technology. 2004 ; Vol. 10, No. 1. pp. 67-70.
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