Motor skill training induces coordinated strengthening and weakening between neighboring synapses

Kea Joo Lee, In Sung Park, Hyun Kim, William T. Greenough, Daniel T S Pak, Im Joo Rhyu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Motor skill training promotes the formation of parallel fiber multiple-synapse boutons (MSBs) contacting dendritic spine pairs of Purkinje cells in the rat cerebellum. However, the dendritic origin of such spine pairs is unknown. Here, we used three-dimensional electron microscopy reconstruction of synaptic connectivity to demonstrate that motor skill training selectively induced MSBs contacting two spines arising from the same dendrite, consistent with strengthening of local synaptic efficacy. However, excitatory synapses near MSBs were smaller in motor-trained animals, suggesting compensatory depression of MSB-neighbor synapses. Concerted strengthening and weakening of adjacent synapses may enhance synaptic weight differences for information encoding while maintaining stable overall activity levels within local dendritic segments.

Original languageEnglish
Pages (from-to)9794-9799
Number of pages6
JournalJournal of Neuroscience
Volume33
Issue number23
DOIs
Publication statusPublished - 2013 Jun 7

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Motor Skills
Synapses
Spine
Dendritic Spines
Purkinje Cells
Dendrites
Cerebellum
Electron Microscopy
Weights and Measures

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Motor skill training induces coordinated strengthening and weakening between neighboring synapses. / Lee, Kea Joo; Park, In Sung; Kim, Hyun; Greenough, William T.; Pak, Daniel T S; Rhyu, Im Joo.

In: Journal of Neuroscience, Vol. 33, No. 23, 07.06.2013, p. 9794-9799.

Research output: Contribution to journalArticle

Lee, Kea Joo ; Park, In Sung ; Kim, Hyun ; Greenough, William T. ; Pak, Daniel T S ; Rhyu, Im Joo. / Motor skill training induces coordinated strengthening and weakening between neighboring synapses. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 23. pp. 9794-9799.
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