MRI-based prostate volume-adjusted prostate-specific antigen in the diagnosis of prostate cancer

Yahui Peng, Dinggang Shen, Shu Liao, Baris Turkbey, Soroush Rais-Bahrami, Bradford Wood, Ibrahim Karademir, Tatjana Antic, Ambereen Yousef, Yulei Jiang, Peter A. Pinto, Peter L. Choyke, Aytekin Oto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose To determine whether prostate-specific antigen (PSA) levels adjusted by prostate and zonal volumes estimated from magnetic resonance imaging (MRI) improve the diagnosis of prostate cancer (PCa) and differentiation between patients who harbor high-Gleason-sum PCa and those without PCa. Materials and Methods This retrospective study was Health Insurance Portability and Accountability Act (HIPAA)-compliant and approved by the Institutional Review Board of participating medical institutions. T2-weighted MR images were acquired for 61 PCa patients and 100 patients with elevated PSA but without PCa. Computer methods were used to segment prostate and zonal structures and to estimate the total prostate and central-gland (CG) volumes, which were then used to calculate CG volume fraction, PSA density, and PSA density adjusted by CG volume. These quantities were used to differentiate patients with and without PCa. Area under the receiver operating characteristic curve (AUC) was used as the figure of merit. Results The total prostate and CG volumes, CG volume fraction, and PSA density adjusted by the total prostate and CG volumes were statistically significantly different between patients with PCa and patients without PCa (P ≤ 0.007). AUC values for the total prostate and CG volumes, and PSA density adjusted by CG volume, were 0.68 ± 0.04, 0.68 ± 0.04, and 0.66 ± 0.04, respectively, and were significantly better than that of PSA (P <0.02), for differentiation of PCa patients from patients without PCa. Conclusion The total prostate and CG volumes estimated from T2-weighted MR images and PSA density adjusted by these volumes can improve the effectiveness of PSA for the diagnosis of PCa and differentiation of high-Gleason-sum PCa patients from patients without PCa.

Original languageEnglish
Pages (from-to)1733-1739
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1
Externally publishedYes

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Prostate-Specific Antigen
Prostate
Prostatic Neoplasms
Magnetic Resonance Imaging
Area Under Curve
Health Insurance Portability and Accountability Act
Research Ethics Committees
ROC Curve
Retrospective Studies

Keywords

  • image segmentation
  • magnetic resonance imaging
  • prostate cancer
  • prostate volume
  • prostate-specific antigen
  • zonal structure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MRI-based prostate volume-adjusted prostate-specific antigen in the diagnosis of prostate cancer. / Peng, Yahui; Shen, Dinggang; Liao, Shu; Turkbey, Baris; Rais-Bahrami, Soroush; Wood, Bradford; Karademir, Ibrahim; Antic, Tatjana; Yousef, Ambereen; Jiang, Yulei; Pinto, Peter A.; Choyke, Peter L.; Oto, Aytekin.

In: Journal of Magnetic Resonance Imaging, Vol. 42, No. 6, 01.12.2015, p. 1733-1739.

Research output: Contribution to journalArticle

Peng, Y, Shen, D, Liao, S, Turkbey, B, Rais-Bahrami, S, Wood, B, Karademir, I, Antic, T, Yousef, A, Jiang, Y, Pinto, PA, Choyke, PL & Oto, A 2015, 'MRI-based prostate volume-adjusted prostate-specific antigen in the diagnosis of prostate cancer', Journal of Magnetic Resonance Imaging, vol. 42, no. 6, pp. 1733-1739. https://doi.org/10.1002/jmri.24944
Peng, Yahui ; Shen, Dinggang ; Liao, Shu ; Turkbey, Baris ; Rais-Bahrami, Soroush ; Wood, Bradford ; Karademir, Ibrahim ; Antic, Tatjana ; Yousef, Ambereen ; Jiang, Yulei ; Pinto, Peter A. ; Choyke, Peter L. ; Oto, Aytekin. / MRI-based prostate volume-adjusted prostate-specific antigen in the diagnosis of prostate cancer. In: Journal of Magnetic Resonance Imaging. 2015 ; Vol. 42, No. 6. pp. 1733-1739.
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abstract = "Purpose To determine whether prostate-specific antigen (PSA) levels adjusted by prostate and zonal volumes estimated from magnetic resonance imaging (MRI) improve the diagnosis of prostate cancer (PCa) and differentiation between patients who harbor high-Gleason-sum PCa and those without PCa. Materials and Methods This retrospective study was Health Insurance Portability and Accountability Act (HIPAA)-compliant and approved by the Institutional Review Board of participating medical institutions. T2-weighted MR images were acquired for 61 PCa patients and 100 patients with elevated PSA but without PCa. Computer methods were used to segment prostate and zonal structures and to estimate the total prostate and central-gland (CG) volumes, which were then used to calculate CG volume fraction, PSA density, and PSA density adjusted by CG volume. These quantities were used to differentiate patients with and without PCa. Area under the receiver operating characteristic curve (AUC) was used as the figure of merit. Results The total prostate and CG volumes, CG volume fraction, and PSA density adjusted by the total prostate and CG volumes were statistically significantly different between patients with PCa and patients without PCa (P ≤ 0.007). AUC values for the total prostate and CG volumes, and PSA density adjusted by CG volume, were 0.68 ± 0.04, 0.68 ± 0.04, and 0.66 ± 0.04, respectively, and were significantly better than that of PSA (P <0.02), for differentiation of PCa patients from patients without PCa. Conclusion The total prostate and CG volumes estimated from T2-weighted MR images and PSA density adjusted by these volumes can improve the effectiveness of PSA for the diagnosis of PCa and differentiation of high-Gleason-sum PCa patients from patients without PCa.",
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T1 - MRI-based prostate volume-adjusted prostate-specific antigen in the diagnosis of prostate cancer

AU - Peng, Yahui

AU - Shen, Dinggang

AU - Liao, Shu

AU - Turkbey, Baris

AU - Rais-Bahrami, Soroush

AU - Wood, Bradford

AU - Karademir, Ibrahim

AU - Antic, Tatjana

AU - Yousef, Ambereen

AU - Jiang, Yulei

AU - Pinto, Peter A.

AU - Choyke, Peter L.

AU - Oto, Aytekin

PY - 2015/12/1

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N2 - Purpose To determine whether prostate-specific antigen (PSA) levels adjusted by prostate and zonal volumes estimated from magnetic resonance imaging (MRI) improve the diagnosis of prostate cancer (PCa) and differentiation between patients who harbor high-Gleason-sum PCa and those without PCa. Materials and Methods This retrospective study was Health Insurance Portability and Accountability Act (HIPAA)-compliant and approved by the Institutional Review Board of participating medical institutions. T2-weighted MR images were acquired for 61 PCa patients and 100 patients with elevated PSA but without PCa. Computer methods were used to segment prostate and zonal structures and to estimate the total prostate and central-gland (CG) volumes, which were then used to calculate CG volume fraction, PSA density, and PSA density adjusted by CG volume. These quantities were used to differentiate patients with and without PCa. Area under the receiver operating characteristic curve (AUC) was used as the figure of merit. Results The total prostate and CG volumes, CG volume fraction, and PSA density adjusted by the total prostate and CG volumes were statistically significantly different between patients with PCa and patients without PCa (P ≤ 0.007). AUC values for the total prostate and CG volumes, and PSA density adjusted by CG volume, were 0.68 ± 0.04, 0.68 ± 0.04, and 0.66 ± 0.04, respectively, and were significantly better than that of PSA (P <0.02), for differentiation of PCa patients from patients without PCa. Conclusion The total prostate and CG volumes estimated from T2-weighted MR images and PSA density adjusted by these volumes can improve the effectiveness of PSA for the diagnosis of PCa and differentiation of high-Gleason-sum PCa patients from patients without PCa.

AB - Purpose To determine whether prostate-specific antigen (PSA) levels adjusted by prostate and zonal volumes estimated from magnetic resonance imaging (MRI) improve the diagnosis of prostate cancer (PCa) and differentiation between patients who harbor high-Gleason-sum PCa and those without PCa. Materials and Methods This retrospective study was Health Insurance Portability and Accountability Act (HIPAA)-compliant and approved by the Institutional Review Board of participating medical institutions. T2-weighted MR images were acquired for 61 PCa patients and 100 patients with elevated PSA but without PCa. Computer methods were used to segment prostate and zonal structures and to estimate the total prostate and central-gland (CG) volumes, which were then used to calculate CG volume fraction, PSA density, and PSA density adjusted by CG volume. These quantities were used to differentiate patients with and without PCa. Area under the receiver operating characteristic curve (AUC) was used as the figure of merit. Results The total prostate and CG volumes, CG volume fraction, and PSA density adjusted by the total prostate and CG volumes were statistically significantly different between patients with PCa and patients without PCa (P ≤ 0.007). AUC values for the total prostate and CG volumes, and PSA density adjusted by CG volume, were 0.68 ± 0.04, 0.68 ± 0.04, and 0.66 ± 0.04, respectively, and were significantly better than that of PSA (P <0.02), for differentiation of PCa patients from patients without PCa. Conclusion The total prostate and CG volumes estimated from T2-weighted MR images and PSA density adjusted by these volumes can improve the effectiveness of PSA for the diagnosis of PCa and differentiation of high-Gleason-sum PCa patients from patients without PCa.

KW - image segmentation

KW - magnetic resonance imaging

KW - prostate cancer

KW - prostate volume

KW - prostate-specific antigen

KW - zonal structure

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