MRI Findings of recurrent hepatocellular carcinoma after liver transplantation: Preliminary results

Chang Hee Lee, Lauren M. Brubaker, David A. Gerber, Young Mi Ku, Young Hoon Kim, Sang Soo Shin, Richard C. Semelka

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    13 Citations (Scopus)

    Abstract

    Purpose To describe the patterns of recurrence and serial magnetic resonance imaging (MRI) features of hepatocellular carcinoma (HCC) after liver transplantation. Materials and Methods All cases of recurrent HCC after transplantation between September 2002 and August 2009 that underwent MRI including precontrast T1, T2-weighted images, and postgadolinium dynamic images were reviewed. On MRI we evaluated the characteristics and patterns of recurrent HCC after transplantation. Results A total 7 of 76 transplanted patients (four men, three women, age range, 45-63, mean 52.7 years) were included in this study. Four patients (57.1%) were identified to have a pattern of persistent local disease (PLD) near the transplanted liver, hepatorenal space, or suture site within 2.75 years (range, 2-4 years). Two patients showed recurrent HCC in the allograft alone within 5 years. One patient showed an intraperitoneal seeding (IPS) pattern which demonstrated diffuse peritoneal infiltration and thickening within 9 months. The diffuse metastatic disease (DMD) pattern was observed as a late manifestation of PLD and IPS. The most prominent volume of recurrent tumor burden was found in an extrahepatic (5 of 7 patients) compared to an intrahepatic (2 of 7 patients) location. The signal intensities and enhancement patterns did not exhibit change with disease progression. Conclusion We describe four patterns of recurrence of HCC following transplant. The most prominent tumor burden was located in an extrahepatic compared to an intrahepatic location.

    Original languageEnglish
    Pages (from-to)1399-1405
    Number of pages7
    JournalJournal of Magnetic Resonance Imaging
    Volume33
    Issue number6
    DOIs
    Publication statusPublished - 2011 Jun

    Keywords

    • MRI
    • hepatocellular carcinoma
    • liver
    • recurrence
    • transplantation

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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