MRI of the knee at 3T: first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence.

Mike Notohamiprodjo, Annie Horng, Matthias F. Pietschmann, Peter E. Müller, Wilhelm Horger, Jaeseok Park, Alexander Crispin, J. R. del Olmo, Sabine Weckbach, Karin A. Herrmann, Maximilian F. Reiser, Christian Glaser

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Abstract

PURPOSE: To clinically evaluate MRI of the knee using a highly resolved isotropic fat-saturated (fs) proton-density weighted 3D-TSE-sequence (SPACE) at 3T. MATERIALS AND METHODS: Imaging was performed on a 3T-scanner (Magnetom TRIO). For technical evaluation, sagittally orientated SPACE-datasets (repetition-time [TR], 1200 milliseconds/[TE], 30 milliseconds/voxel-size, 0.5 mm3/acquisition time, 10:35 minutes) were acquired from the dominant knee of 10 healthy volunteers. In the 3 major anatomic planes, 0.5, 1, and 2 mm thick reconstructions were performed. Signal-to-noise (SNR), SNR-efficiency, contrast-to-noise (CNR) ratios, and anatomic detail visualization were compared with a state-of-the-art 2D-TSE-sequence in 3 imaging planes (TR, 3200 milliseconds/TE, 30 milliseconds/acquisition time, 12:34 minutes). Sixty patients with cartilage and meniscus pathologies were examined with these techniques. Patient SPACE-datasets were assessed in 1-mm thick reconstructions. Arthroscopical correlation was available for 18 patients. Lesion detection and diagnostic confidence were assessed by 2 radiologists independently. Statistical analysis was performed using 95% confidence intervals, Wilcoxon signed rank tests, and Weighted-kappa. RESULTS: SNR-efficiency of SPACE was 4 to 5 times higher than for 2D-TSE-sequences. SNR and CNR of 1-mm thick SPACE-reconstructions were comparable to 2D-TSE-sequences and provided superior visualization of small structures such as meniscal roots.Correlation with arthroscopy did not show significant differences between 2D- and 3D-sequences. One reader detected significantly more cartilage abnormalities with the 2D-TSE-sequence (131 vs. 151, P = 0.04), probably because of an unfamiliar fluid/cartilage contrast. Diagnostic confidence was significantly higher for meniscus abnormalities for SPACE for 1 reader. Intersequence-correlation was excellent (kappa = 0.82-0.92). Interreader-correlation was good to excellent (kappa = 0.71-0.80), intrareader-correlation was excellent (kappa = 0.90-0.92) for both sequences. CONCLUSIONS: Time-efficient 3D-TSE-imaging of the knee at 3T is feasible with adequate SNR and CNR and excellent anatomic detail visualization. Detection and visualization of meniscus and cartilage pathologies is comparable to standard 2D-TSE-sequences. 3D-TSE-sequences with consecutive multiplanar reconstruction may become a valuable component of future knee-MRI protocols.

Original languageEnglish
Pages (from-to)585-597
Number of pages13
JournalInvestigative Radiology
Volume44
Issue number9
Publication statusPublished - 2009 Sep 1

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Cartilage
Noise
Knee
Pathology
Arthroscopy
Nonparametric Statistics
Protons
Healthy Volunteers
Fats
Confidence Intervals
Meniscus
Datasets

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Notohamiprodjo, M., Horng, A., Pietschmann, M. F., Müller, P. E., Horger, W., Park, J., ... Glaser, C. (2009). MRI of the knee at 3T: first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence. Investigative Radiology, 44(9), 585-597.

MRI of the knee at 3T : first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence. / Notohamiprodjo, Mike; Horng, Annie; Pietschmann, Matthias F.; Müller, Peter E.; Horger, Wilhelm; Park, Jaeseok; Crispin, Alexander; del Olmo, J. R.; Weckbach, Sabine; Herrmann, Karin A.; Reiser, Maximilian F.; Glaser, Christian.

In: Investigative Radiology, Vol. 44, No. 9, 01.09.2009, p. 585-597.

Research output: Contribution to journalArticle

Notohamiprodjo, M, Horng, A, Pietschmann, MF, Müller, PE, Horger, W, Park, J, Crispin, A, del Olmo, JR, Weckbach, S, Herrmann, KA, Reiser, MF & Glaser, C 2009, 'MRI of the knee at 3T: first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence.', Investigative Radiology, vol. 44, no. 9, pp. 585-597.
Notohamiprodjo M, Horng A, Pietschmann MF, Müller PE, Horger W, Park J et al. MRI of the knee at 3T: first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence. Investigative Radiology. 2009 Sep 1;44(9):585-597.
Notohamiprodjo, Mike ; Horng, Annie ; Pietschmann, Matthias F. ; Müller, Peter E. ; Horger, Wilhelm ; Park, Jaeseok ; Crispin, Alexander ; del Olmo, J. R. ; Weckbach, Sabine ; Herrmann, Karin A. ; Reiser, Maximilian F. ; Glaser, Christian. / MRI of the knee at 3T : first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence. In: Investigative Radiology. 2009 ; Vol. 44, No. 9. pp. 585-597.
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abstract = "PURPOSE: To clinically evaluate MRI of the knee using a highly resolved isotropic fat-saturated (fs) proton-density weighted 3D-TSE-sequence (SPACE) at 3T. MATERIALS AND METHODS: Imaging was performed on a 3T-scanner (Magnetom TRIO). For technical evaluation, sagittally orientated SPACE-datasets (repetition-time [TR], 1200 milliseconds/[TE], 30 milliseconds/voxel-size, 0.5 mm3/acquisition time, 10:35 minutes) were acquired from the dominant knee of 10 healthy volunteers. In the 3 major anatomic planes, 0.5, 1, and 2 mm thick reconstructions were performed. Signal-to-noise (SNR), SNR-efficiency, contrast-to-noise (CNR) ratios, and anatomic detail visualization were compared with a state-of-the-art 2D-TSE-sequence in 3 imaging planes (TR, 3200 milliseconds/TE, 30 milliseconds/acquisition time, 12:34 minutes). Sixty patients with cartilage and meniscus pathologies were examined with these techniques. Patient SPACE-datasets were assessed in 1-mm thick reconstructions. Arthroscopical correlation was available for 18 patients. Lesion detection and diagnostic confidence were assessed by 2 radiologists independently. Statistical analysis was performed using 95{\%} confidence intervals, Wilcoxon signed rank tests, and Weighted-kappa. RESULTS: SNR-efficiency of SPACE was 4 to 5 times higher than for 2D-TSE-sequences. SNR and CNR of 1-mm thick SPACE-reconstructions were comparable to 2D-TSE-sequences and provided superior visualization of small structures such as meniscal roots.Correlation with arthroscopy did not show significant differences between 2D- and 3D-sequences. One reader detected significantly more cartilage abnormalities with the 2D-TSE-sequence (131 vs. 151, P = 0.04), probably because of an unfamiliar fluid/cartilage contrast. Diagnostic confidence was significantly higher for meniscus abnormalities for SPACE for 1 reader. Intersequence-correlation was excellent (kappa = 0.82-0.92). Interreader-correlation was good to excellent (kappa = 0.71-0.80), intrareader-correlation was excellent (kappa = 0.90-0.92) for both sequences. CONCLUSIONS: Time-efficient 3D-TSE-imaging of the knee at 3T is feasible with adequate SNR and CNR and excellent anatomic detail visualization. Detection and visualization of meniscus and cartilage pathologies is comparable to standard 2D-TSE-sequences. 3D-TSE-sequences with consecutive multiplanar reconstruction may become a valuable component of future knee-MRI protocols.",
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T2 - first clinical results with an isotropic PDfs-weighted 3D-TSE-sequence.

AU - Notohamiprodjo, Mike

AU - Horng, Annie

AU - Pietschmann, Matthias F.

AU - Müller, Peter E.

AU - Horger, Wilhelm

AU - Park, Jaeseok

AU - Crispin, Alexander

AU - del Olmo, J. R.

AU - Weckbach, Sabine

AU - Herrmann, Karin A.

AU - Reiser, Maximilian F.

AU - Glaser, Christian

PY - 2009/9/1

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N2 - PURPOSE: To clinically evaluate MRI of the knee using a highly resolved isotropic fat-saturated (fs) proton-density weighted 3D-TSE-sequence (SPACE) at 3T. MATERIALS AND METHODS: Imaging was performed on a 3T-scanner (Magnetom TRIO). For technical evaluation, sagittally orientated SPACE-datasets (repetition-time [TR], 1200 milliseconds/[TE], 30 milliseconds/voxel-size, 0.5 mm3/acquisition time, 10:35 minutes) were acquired from the dominant knee of 10 healthy volunteers. In the 3 major anatomic planes, 0.5, 1, and 2 mm thick reconstructions were performed. Signal-to-noise (SNR), SNR-efficiency, contrast-to-noise (CNR) ratios, and anatomic detail visualization were compared with a state-of-the-art 2D-TSE-sequence in 3 imaging planes (TR, 3200 milliseconds/TE, 30 milliseconds/acquisition time, 12:34 minutes). Sixty patients with cartilage and meniscus pathologies were examined with these techniques. Patient SPACE-datasets were assessed in 1-mm thick reconstructions. Arthroscopical correlation was available for 18 patients. Lesion detection and diagnostic confidence were assessed by 2 radiologists independently. Statistical analysis was performed using 95% confidence intervals, Wilcoxon signed rank tests, and Weighted-kappa. RESULTS: SNR-efficiency of SPACE was 4 to 5 times higher than for 2D-TSE-sequences. SNR and CNR of 1-mm thick SPACE-reconstructions were comparable to 2D-TSE-sequences and provided superior visualization of small structures such as meniscal roots.Correlation with arthroscopy did not show significant differences between 2D- and 3D-sequences. One reader detected significantly more cartilage abnormalities with the 2D-TSE-sequence (131 vs. 151, P = 0.04), probably because of an unfamiliar fluid/cartilage contrast. Diagnostic confidence was significantly higher for meniscus abnormalities for SPACE for 1 reader. Intersequence-correlation was excellent (kappa = 0.82-0.92). Interreader-correlation was good to excellent (kappa = 0.71-0.80), intrareader-correlation was excellent (kappa = 0.90-0.92) for both sequences. CONCLUSIONS: Time-efficient 3D-TSE-imaging of the knee at 3T is feasible with adequate SNR and CNR and excellent anatomic detail visualization. Detection and visualization of meniscus and cartilage pathologies is comparable to standard 2D-TSE-sequences. 3D-TSE-sequences with consecutive multiplanar reconstruction may become a valuable component of future knee-MRI protocols.

AB - PURPOSE: To clinically evaluate MRI of the knee using a highly resolved isotropic fat-saturated (fs) proton-density weighted 3D-TSE-sequence (SPACE) at 3T. MATERIALS AND METHODS: Imaging was performed on a 3T-scanner (Magnetom TRIO). For technical evaluation, sagittally orientated SPACE-datasets (repetition-time [TR], 1200 milliseconds/[TE], 30 milliseconds/voxel-size, 0.5 mm3/acquisition time, 10:35 minutes) were acquired from the dominant knee of 10 healthy volunteers. In the 3 major anatomic planes, 0.5, 1, and 2 mm thick reconstructions were performed. Signal-to-noise (SNR), SNR-efficiency, contrast-to-noise (CNR) ratios, and anatomic detail visualization were compared with a state-of-the-art 2D-TSE-sequence in 3 imaging planes (TR, 3200 milliseconds/TE, 30 milliseconds/acquisition time, 12:34 minutes). Sixty patients with cartilage and meniscus pathologies were examined with these techniques. Patient SPACE-datasets were assessed in 1-mm thick reconstructions. Arthroscopical correlation was available for 18 patients. Lesion detection and diagnostic confidence were assessed by 2 radiologists independently. Statistical analysis was performed using 95% confidence intervals, Wilcoxon signed rank tests, and Weighted-kappa. RESULTS: SNR-efficiency of SPACE was 4 to 5 times higher than for 2D-TSE-sequences. SNR and CNR of 1-mm thick SPACE-reconstructions were comparable to 2D-TSE-sequences and provided superior visualization of small structures such as meniscal roots.Correlation with arthroscopy did not show significant differences between 2D- and 3D-sequences. One reader detected significantly more cartilage abnormalities with the 2D-TSE-sequence (131 vs. 151, P = 0.04), probably because of an unfamiliar fluid/cartilage contrast. Diagnostic confidence was significantly higher for meniscus abnormalities for SPACE for 1 reader. Intersequence-correlation was excellent (kappa = 0.82-0.92). Interreader-correlation was good to excellent (kappa = 0.71-0.80), intrareader-correlation was excellent (kappa = 0.90-0.92) for both sequences. CONCLUSIONS: Time-efficient 3D-TSE-imaging of the knee at 3T is feasible with adequate SNR and CNR and excellent anatomic detail visualization. Detection and visualization of meniscus and cartilage pathologies is comparable to standard 2D-TSE-sequences. 3D-TSE-sequences with consecutive multiplanar reconstruction may become a valuable component of future knee-MRI protocols.

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