MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee; Jane Melissa Lim; Hyunchu Cho; Eunju Kim; Yeonsil Kim; Hye Kyung Oh; Woo Seok Yang; Kyung Hye Roh; Hyun Woo Park; Jung Soon Mo; Je Hyun Yoon; Hyun Kyu Song; Eui Ju Choi

doi:10.1016/j.molcel.2019.01.022

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee, Jane Melissa Lim, Hyunchu Cho, Eunju Kim, Yeonsil Kim, Hye Kyung Oh, Woo Seok Yang, Kyung Hye Roh, Hyun Woo Park, Jung Soon Mo, Je Hyun Yoon, Hyun Kyu Song, Eui Ju Choi

Division of Life Sciences

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

Original language	English
Pages (from-to)	1138-1149.e6
Journal	Molecular Cell
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.01.022
Publication status	Published - 2019 Mar 21

Keywords

HOIP
LUBAC
MST1
NF-κB
TNFα
TNFα receptor 1 signaling complex
TRAF2
inflammation
macrophage
ubiquitination

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.01.022

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Lee, I. Y., Lim, J. M., Cho, H., Kim, E., Kim, Y., Oh, H. K., Yang, W. S., Roh, K. H., Park, H. W., Mo, J. S., Yoon, J. H., Song, H. K., & Choi, E. J. (2019). MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. Molecular Cell, 73(6), 1138-1149.e6. https://doi.org/10.1016/j.molcel.2019.01.022

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. / Lee, In Young; Lim, Jane Melissa; Cho, Hyunchu; Kim, Eunju; Kim, Yeonsil; Oh, Hye Kyung; Yang, Woo Seok; Roh, Kyung Hye; Park, Hyun Woo; Mo, Jung Soon; Yoon, Je Hyun; Song, Hyun Kyu ; Choi, Eui Ju.

In: Molecular Cell, Vol. 73, No. 6, 21.03.2019, p. 1138-1149.e6.

Research output: Contribution to journal › Article

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abstract = "Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.",

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