MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee, Jane Melissa Lim, Hyunchu Cho, Eunju Kim, Yeonsil Kim, Hye Kyung Oh, Woo Seok Yang, Kyung Hye Roh, Hyun Woo Park, Jung Soon Mo, Je Hyun Yoon, Hyun Kyu Song, Eui Ju Choi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

Original languageEnglish
Pages (from-to)1138-1149.e6
JournalMolecular Cell
Volume73
Issue number6
DOIs
Publication statusPublished - 2019 Mar 21

Keywords

  • HOIP
  • LUBAC
  • MST1
  • NF-κB
  • TNFα
  • TNFα receptor 1 signaling complex
  • TRAF2
  • inflammation
  • macrophage
  • ubiquitination

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Lee, I. Y., Lim, J. M., Cho, H., Kim, E., Kim, Y., Oh, H. K., Yang, W. S., Roh, K. H., Park, H. W., Mo, J. S., Yoon, J. H., Song, H. K., & Choi, E. J. (2019). MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. Molecular Cell, 73(6), 1138-1149.e6. https://doi.org/10.1016/j.molcel.2019.01.022