@article{82631f4a3a604b93b14b6e68d0c1a1fc,
title = "MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity",
abstract = "Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.",
keywords = "HOIP, LUBAC, MST1, NF-κB, TNFα, TNFα receptor 1 signaling complex, TRAF2, inflammation, macrophage, ubiquitination",
author = "Lee, {In Young} and Lim, {Jane Melissa} and Hyunchu Cho and Eunju Kim and Yeonsil Kim and Oh, {Hye Kyung} and Yang, {Woo Seok} and Roh, {Kyung Hye} and Park, {Hyun Woo} and Mo, {Jung Soon} and Yoon, {Je Hyun} and Song, {Hyun Kyu} and Choi, {Eui Ju}",
note = "Funding Information: We thank K. Iwai for GST-hTNFα(77–233) cDNA, S. Yonehara for Flag-MST1 cDNA, V.M. Dixit for antibody to linear ubiquitin, S.Y. Lee for TRAF2 +/+ or TRAF2 − / − MEFs, and D.S. Lim for MST1 − / − mice. This work was supported by a National Research Foundation grant ( NRF-2017R1A2B2008193 ) and by a BRL grant ( NRF-2015R1A4A1041919 ) funded by the Ministry of Science and ICT of Korea as well as by a Korea University grant (E.-J.C.). ",
year = "2019",
month = mar,
day = "21",
doi = "10.1016/j.molcel.2019.01.022",
language = "English",
volume = "73",
pages = "1138--1149.e6",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}