Muju virus, harbored by myodes regulus in korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus

Jin Goo Lee, Se Hun Gu, Luck Ju Baek, Ok Shin, Kwang Sook Park, Heung Chul Kim, Terry A. Klein, Richard Yanagihara, Jin Won Song

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The genome of Muju virus (MUJV), identified originally in the royal vole (Myodes regulus) in Korea, was fully sequenced to ascertain its genetic and phylogenetic relationship with Puumala virus (PUUV), harbored by the bank vole (My. glareolus), and a PUUV-like virus, named Hokkaido virus (HOKV), in the grey red-backed vole (My. rufocanus) in Japan. Whole genome sequence analysis of the 6544-nucleotide large (L), 3652-nucleotide medium (M) and 1831-nucleotide small (S) segments of MUJV, as well as the amino acid sequences of their gene products, indicated that MUJV strains from different capture sites might represent genetic variants of PUUV, the prototype arvicolid rodent-borne hantavirus in Europe. Distinct geographic-specific clustering of MUJV was found in different provinces in Korea, and phylogenetic analyses revealed that MUJV and HOKV share a common ancestry with PUUV. A better understanding of the taxonomic classification and pathogenic potential of MUJV must await its isolation in cell culture.

Original languageEnglish
Pages (from-to)1701-1714
Number of pages14
JournalViruses
Volume6
Issue number4
DOIs
Publication statusPublished - 2014 Apr 14

Fingerprint

Puumala virus
Hantavirus
Arvicolinae
Korea
Rodentia
Viruses
Nucleotides
Genome
Sequence Analysis
Cluster Analysis
Amino Acid Sequence
Japan
Cell Culture Techniques

Keywords

  • Hantavirus
  • Muju virus
  • Myodes regulus
  • Phylogeny

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Muju virus, harbored by myodes regulus in korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus. / Lee, Jin Goo; Gu, Se Hun; Baek, Luck Ju; Shin, Ok; Park, Kwang Sook; Kim, Heung Chul; Klein, Terry A.; Yanagihara, Richard; Song, Jin Won.

In: Viruses, Vol. 6, No. 4, 14.04.2014, p. 1701-1714.

Research output: Contribution to journalArticle

Lee, Jin Goo ; Gu, Se Hun ; Baek, Luck Ju ; Shin, Ok ; Park, Kwang Sook ; Kim, Heung Chul ; Klein, Terry A. ; Yanagihara, Richard ; Song, Jin Won. / Muju virus, harbored by myodes regulus in korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus. In: Viruses. 2014 ; Vol. 6, No. 4. pp. 1701-1714.
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