Multi-component nanorods for vaccination applications

A. K. Salem, C. F. Hung, Tae Woo Kim, T. C. Wu, P. C. Searson, K. W. Leong

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CDS T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.

Original languageEnglish
Pages (from-to)484-487
Number of pages4
JournalNanotechnology
Volume16
Issue number4
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Engineering (miscellaneous)
  • Materials Science(all)
  • Physics and Astronomy (miscellaneous)

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  • Cite this

    Salem, A. K., Hung, C. F., Kim, T. W., Wu, T. C., Searson, P. C., & Leong, K. W. (2005). Multi-component nanorods for vaccination applications. Nanotechnology, 16(4), 484-487. https://doi.org/10.1088/0957-4484/16/4/025