Multi-contrast diffusion tensor image registration with structural MRI

Xiujuan Geng, Martin Styner, Aditya Gupta, Dinggang Shen, John H. Gilmore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We present a diffeomorphic diffusion tensor image (DTI) registration technique with multi-contrast images extracted from DTI and conventional structural MRI data. DTI provides microstructure information in white matter. However due to the acquisition protocols used in many clinical studies, DTI has lower SNR and spatial resolution compared to structural MRI. Complementary information can be used to improve the registration of white and gray matter. The proposed registration framework is constructed by a vector-valued large deformation diffeomorphic demons approach. Fractional anisotropy (FA) and eigenvalues are included as DTI components. T1-weighted image serves as the structural MRI component. The performance of the proposed method is compared with DTI only multi-contrast and full tensor based registration methods. Incorporation of structural data reduces FA variance in white matter adjacent to cortical regions. Compared to tensor based registration, the multi-contrast methods generate smaller shape variance but less directional consistency. We also demonstrate that the proposed method reduces fiber tract variations across individuals and creates a denser fiber tract probability map compared to DTI based registrations.

Original languageEnglish
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages684-687
Number of pages4
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: 2012 May 22012 May 5

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period12/5/212/5/5

Keywords

  • Diffusion tensor imaging
  • T1-weighted (T1 w) MRI
  • diffeomorphic demons
  • multi-contrast registration

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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