Multi-core vesicle nanoparticles for controlled delivery of protein drug

Soon Hong Yuk, Keun Sang Oh, Seung Ki Kim, Jin Ho Lee, Sun Hang Cho, Kwangmeyung Kim, Hyesung Jeon, Ick Chan Kwon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalMacromolecular Research
Volume20
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1

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Keywords

  • Human growth hormone
  • Multi-core vesicle NPs
  • Peptide drug
  • Pluronic/PEG composite NPs
  • Sustained release

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Yuk, S. H., Oh, K. S., Kim, S. K., Lee, J. H., Cho, S. H., Kim, K., Jeon, H., & Kwon, I. C. (2012). Multi-core vesicle nanoparticles for controlled delivery of protein drug. Macromolecular Research, 20(3), 309-312. https://doi.org/10.1007/s13233-012-0053-y