Abstract
Understanding human brain functional development in the very early ages is of great importance for charting normative development and detecting early neurodevelopmental disorders, but it is very challenging. We propose a group-constrained, robust community detection method for better understanding of developing brain functional connectome from neonate to two-year-old. For such a multi-subject, multi-age-group network topology study, we build a multi-layer functional network by adding inter-subject edges, and detect modular structure (communities) to explore topological changes of multiple functional systems at different ages and across subjects. This “Multi-Layer Inter-Subject-Constrained Modularity Analysis (MLISMA)” can detect group consistent modules without losing individual information, thus allowing assessment of individual variability in the brain modular topology, a key metric for developmental individualized fingerprinting. We propose a heuristic parameter optimization strategy to wisely determine the necessary parameters that define the modular configuration. Our method is validated to be feasible using longitudinal 0–1–2 year’s old infant brain functional MRI data, and reveals novel developmental trajectories of brain functional connectome.
| Original language | English |
|---|---|
| Title of host publication | Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings |
| Editors | Alejandro F. Frangi, Christos Davatzikos, Gabor Fichtinger, Carlos Alberola-López, Julia A. Schnabel |
| Publisher | Springer Verlag |
| Pages | 136-144 |
| Number of pages | 9 |
| ISBN (Print) | 9783030009304 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
| Externally published | Yes |
| Event | 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain Duration: 2018 Sep 16 → 2018 Sep 20 |
Publication series
| Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
|---|---|
| Volume | 11072 LNCS |
| ISSN (Print) | 0302-9743 |
| ISSN (Electronic) | 1611-3349 |
Other
| Other | 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 |
|---|---|
| Country | Spain |
| City | Granada |
| Period | 18/9/16 → 18/9/20 |
Fingerprint
Keywords
- Brain network
- Connectome
- Development
- Infant
- Modularity
ASJC Scopus subject areas
- Theoretical Computer Science
- Computer Science(all)
Cite this
Multi-layer large-scale functional connectome reveals infant brain developmental patterns. / Zhang, Han; Stanley, Natalie; Mucha, Peter J.; Yin, Weiyan; Lin, Weili; Shen, Dinggang.
Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. ed. / Alejandro F. Frangi; Christos Davatzikos; Gabor Fichtinger; Carlos Alberola-López; Julia A. Schnabel. Springer Verlag, 2018. p. 136-144 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11072 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Multi-layer large-scale functional connectome reveals infant brain developmental patterns
AU - Zhang, Han
AU - Stanley, Natalie
AU - Mucha, Peter J.
AU - Yin, Weiyan
AU - Lin, Weili
AU - Shen, Dinggang
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Understanding human brain functional development in the very early ages is of great importance for charting normative development and detecting early neurodevelopmental disorders, but it is very challenging. We propose a group-constrained, robust community detection method for better understanding of developing brain functional connectome from neonate to two-year-old. For such a multi-subject, multi-age-group network topology study, we build a multi-layer functional network by adding inter-subject edges, and detect modular structure (communities) to explore topological changes of multiple functional systems at different ages and across subjects. This “Multi-Layer Inter-Subject-Constrained Modularity Analysis (MLISMA)” can detect group consistent modules without losing individual information, thus allowing assessment of individual variability in the brain modular topology, a key metric for developmental individualized fingerprinting. We propose a heuristic parameter optimization strategy to wisely determine the necessary parameters that define the modular configuration. Our method is validated to be feasible using longitudinal 0–1–2 year’s old infant brain functional MRI data, and reveals novel developmental trajectories of brain functional connectome.
AB - Understanding human brain functional development in the very early ages is of great importance for charting normative development and detecting early neurodevelopmental disorders, but it is very challenging. We propose a group-constrained, robust community detection method for better understanding of developing brain functional connectome from neonate to two-year-old. For such a multi-subject, multi-age-group network topology study, we build a multi-layer functional network by adding inter-subject edges, and detect modular structure (communities) to explore topological changes of multiple functional systems at different ages and across subjects. This “Multi-Layer Inter-Subject-Constrained Modularity Analysis (MLISMA)” can detect group consistent modules without losing individual information, thus allowing assessment of individual variability in the brain modular topology, a key metric for developmental individualized fingerprinting. We propose a heuristic parameter optimization strategy to wisely determine the necessary parameters that define the modular configuration. Our method is validated to be feasible using longitudinal 0–1–2 year’s old infant brain functional MRI data, and reveals novel developmental trajectories of brain functional connectome.
KW - Brain network
KW - Connectome
KW - Development
KW - Infant
KW - Modularity
UR - http://www.scopus.com/inward/record.url?scp=85053917092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053917092&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-00931-1_16
DO - 10.1007/978-3-030-00931-1_16
M3 - Conference contribution
AN - SCOPUS:85053917092
SN - 9783030009304
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 136
EP - 144
BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
A2 - Frangi, Alejandro F.
A2 - Davatzikos, Christos
A2 - Fichtinger, Gabor
A2 - Alberola-López, Carlos
A2 - Schnabel, Julia A.
PB - Springer Verlag
ER -