Multi-modality canonical feature selection for Alzheimer's disease diagnosis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

Feature selection has been commonly regarded as an effective method to lessen the problem of high dimension and low sample size in medical image analysis. In this paper, we propose a novel multi-modality canonical feature selection method. Unlike the conventional sparse Multi-Task Learning (MTL) based feature selection method that mostly considered only the relationship between target response variables, we further consider the correlations between features of different modalities by projecting them into a canonical space determined by canonical correlation analysis. We call the projections as canonical representations. By setting the canonical representations as regressors in a sparse least square regression framework and by further penalizing the objective function with a new canonical regularizer on the weight coefficient matrix, we formulate a multi-modality canonical feature selection method. With the help of the canonical information of canonical representations and also a canonical regularizer, the proposed method selects canonical-cross-modality features that are useful for the tasks of clinical scores regression and multi-class disease identification. In our experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, we combine Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) images to jointly predict clinical scores of Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) and also identify multi-class disease status for Alzheimer's disease diagnosis.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings
PublisherSpringer Verlag
Pages162-169
Number of pages8
EditionPART 2
ISBN (Print)9783319104690
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - Boston, MA, United States
Duration: 2014 Sep 142014 Sep 18

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume8674 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014
CountryUnited States
CityBoston, MA
Period14/9/1414/9/18

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Zhu, X., Suk, H. I., & Shen, D. (2014). Multi-modality canonical feature selection for Alzheimer's disease diagnosis. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings (PART 2 ed., pp. 162-169). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 8674 LNCS, No. PART 2). Springer Verlag. https://doi.org/10.1007/978-3-319-10470-6_21