Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus

Byeongha Jeong, Jin Hee Hong, Hyun Kim, Han Kyoung Choe, Kyungjin Kim, Kyoung J. Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The suprachiasmatic nucleus (SCN) is a group of cells that functions as a biological master clock. In different SCN cells, oscillations of biochemical markers such as the expression-level of clock genes, are not synchronized but instead form slow circadian phase waves propagating over the whole cell population spatiooral struc-ture is a fixed property set by the anatomy of a given SCN. Here, we show that this is not the case in early postnatal SCN. Earlier studies presumed that their Based on bioluminescence imaging experiments with Per2-Luciferase mice SCN cultures which guided computer simulations of a realistic model of the SCN, we demonstrate that the wave is not unique but can be in various modes including phase-coherent oscillation, crescent-shaped wave, and most notably, a rotating pinwheel wave that conceptually resembles a wall clock with a rotating hand. Furthermore, mode transitions can be induced by a pulse of 38.5 °C temperature perturbation. Importantly, the waves support a significantly different period, suggesting that neither a spatially-fixed phase ordering nor a specialized pacemaker having a fixed period exist in these studied SCNs. These results lead to new important questions of what the observed multi-stability means for the proper function of an SCN and its arrhythmia.

Original languageEnglish
Article number21463
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 19

ASJC Scopus subject areas

  • General

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