Multicenter prospective study of laparoscopic nissen fundoplication for gastroesophageal reflux disease in korea

Sungsoo Park, Joong Min Park, Jin Jo Kim, In Seob Lee, Sang Uk Han, Kyung Won Seo, Jin Won Kwon

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)


    Backgrounds/Aims This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD). Methods Patients with GERD who were undergoing medical treatment with proton pump inhibitors for more than 8 weeks and those who were scheduled to undergo anti-reflux surgery were enrolled. Efficacy of pre-operative medical treatment was evaluated retrospectively and effect of anti-reflux surgery was prospectively evaluated at 1 week and 3 months after surgery. Quality of life (QOL) was also investigated before and after surgery. Results Between February and October 2018, 51 patients underwent laparoscopic Nissen fundoplication for treating GERD at 5 hospitals in Korea. Thirty-four patients (66.7%) showed poor proton pump inhibitor response. At 3 months after surgery, heartburn was completely resolved in 87.9% patients and partially improved in 9.1%. Acid regurgitation was completely resolved in 82.9% and partially improved in 11.4%. Atypical extraesophageal symptoms were completely controlled in 45.5% and partially controlled in 36.4%. GERD-related QOL scores at 1 week after surgery significantly improved compared with pre-operative scores. There was no difference in GERD-related QOL scores between 1 week and 3 months after surgery. General QOL measured with European QOL-5 dimensions and health-related QOL instrument with 8 items significantly improved after anti-reflux surgery. Satisfaction with treatment was significantly higher after surgery than before surgery (72.5% vs 11.8%, P < 0.001). Conclusion Anti-reflux surgery improved GERD symptoms and QOL in patients. Anti-reflux surgery is an effective treatment option compared with medical treatment for GERD patients selected for surgical treatment.

    Original languageEnglish
    Pages (from-to)394-402
    Number of pages9
    JournalJournal of Neurogastroenterology and Motility
    Issue number3
    Publication statusPublished - 2019


    • Fundoplication
    • Gastroesophageal reflux
    • Laparoscopy
    • Quality of life

    ASJC Scopus subject areas

    • Clinical Neurology
    • Gastroenterology


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