Multicentre phase II trial of bevacizumab combined with docetaxel-carboplatin for the neoadjuvant treatment of triple-negative breast cancer (KCSGBR-0905)

H. R. Kim, K. H. Jung, S. A. Im, Y. H. Im, S. Y. Kang, K. H. Park, S. Lee, S. B. Kim, K. H. Lee, J. S. Ahn, S. I. Kim, J. H. Sohn

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Abstract

Background: This phase II neoadjuvant trial evaluated bevacizumab-docetaxel and carboplatin in triple-negative breast cancer. Patients and methods: Women with hormone receptor- and human epidermal growth factor receptor 2 (HER2)- negative, stage II/III breast cancer received six cycles of 75 mg/m2 docetaxel, carboplatin (AUC = 5) and 15 mg/kg bevacizumab every 21 days. The primary end point was pathological complete response (pCR) in breasts and axillary lymph nodes (ALN). Results: Forty-five patients were recruited from the Korean Cancer Study Group. The median age was 45 (range 30-72) years. ALNs were positive in 80% of patients (n = 36) at diagnosis. Overall, 98% of patients (n = 44) completed therapy and underwent surgery. The pCR rate was 42% (n = 19); clinical response rate 96% (n = 43); complete 13% (n = 6); partial 82% (n = 37); stable disease 2% (n = 1). Breast-conserving surgery was undertaken in 78% of patients (n = 35). Most frequent grade 3/4 adverse events were neutropenia (84%, n = 38) and febrile neutropenia (9%, n = 4). One patient experienced delayed wound healing after surgery. Conclusions: Neoadjuvant bevacizumab, docetaxel and carboplatin resulted in an encouraging pCR rate and negligible wound healing problems after surgery.

Original languageEnglish
Pages (from-to)1485-1490
Number of pages6
JournalAnnals of Oncology
Volume24
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • Bevacizumab
  • Carboplatin
  • Docetaxel
  • Neoadjuvant chemotherapy
  • Pathological complete response
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Kim, H. R., Jung, K. H., Im, S. A., Im, Y. H., Kang, S. Y., Park, K. H., Lee, S., Kim, S. B., Lee, K. H., Ahn, J. S., Kim, S. I., & Sohn, J. H. (2013). Multicentre phase II trial of bevacizumab combined with docetaxel-carboplatin for the neoadjuvant treatment of triple-negative breast cancer (KCSGBR-0905). Annals of Oncology, 24(6), 1485-1490. https://doi.org/10.1093/annonc/mds658