Multichannel surface electrodes increase the sensitivity of diagnosis of neuropathy in diabetic patients

Yong Seo Koo, Ki Young Jung, Sang Hoon Lee, Charles S. Cho, Kyung Sook Yang, Jae Hong Jang, Byung Jo Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This prospective study investigated the diagnostic sensitivity of a novel multichannel surface electrode for detecting electrophysiologic changes in symptomatic diabetic neuropathy. We recruited healthy subjects without neuropathic complaints and diabetic patients with distal symmetric sensory symptoms who had normal nerve conduction studies (NCS). Eight compound muscle action potentials (CMAPs) were recorded using a multichannel electrode from each subject's abductor pollicis brevis muscle by stimulating the median nerve at the wrist. Latency- and amplitude-related variables were obtained and analyzed to compare the two groups. We used the Classification and Regression Tree (CART) algorithm to determine the cut-off values for selected predictors of diabetic neuropathy. All of the variables related to CMAP latency showed statistically significant differences between the median values for the diabetic group and the healthy control group. For example, the median value of the maximum latency and standard deviation of the eight CMAP onset latencies in diabetic patients (3.82. ms and 0.15. ms, respectively) were significantly larger than those in controls (3.26. ms and p<0.001; 0.09. ms and p<0.001, respectively). The CART analysis revealed that these variables were the most sensitive and specific variables for discriminating between patients with diabetic neuropathy and normal subjects. The multichannel surface electrode demonstrated both high sensitivity and specificity in detecting neurophysiologic abnormality of diabetic neuropathy, even when conventional NCS did not detect the abnormality.

Original languageEnglish
Pages (from-to)1057-1064
Number of pages8
JournalJournal of Electromyography and Kinesiology
Volume23
Issue number5
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Diabetic Neuropathies
Electrodes
Action Potentials
Muscles
Neural Conduction
Median Nerve
Wrist
Healthy Volunteers
Regression Analysis
Prospective Studies
Sensitivity and Specificity
Control Groups

Keywords

  • Compound muscle action potentials
  • Diabetic neuropathies
  • Early diagnosis
  • Multichannel electrode
  • Nerve conduction study
  • Neural conduction

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biophysics
  • Clinical Neurology

Cite this

Multichannel surface electrodes increase the sensitivity of diagnosis of neuropathy in diabetic patients. / Koo, Yong Seo; Jung, Ki Young; Lee, Sang Hoon; Cho, Charles S.; Yang, Kyung Sook; Jang, Jae Hong; Kim, Byung Jo.

In: Journal of Electromyography and Kinesiology, Vol. 23, No. 5, 01.10.2013, p. 1057-1064.

Research output: Contribution to journalArticle

Koo, Yong Seo ; Jung, Ki Young ; Lee, Sang Hoon ; Cho, Charles S. ; Yang, Kyung Sook ; Jang, Jae Hong ; Kim, Byung Jo. / Multichannel surface electrodes increase the sensitivity of diagnosis of neuropathy in diabetic patients. In: Journal of Electromyography and Kinesiology. 2013 ; Vol. 23, No. 5. pp. 1057-1064.
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