Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting

Sei Won Lee, Kyeongman Jeon, Kwang Hyun Kim, Kyung-Hoon Min

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from January 2001 to December 2006 were enrolled in the study. Drug resistant Mycobacterium tuberculosis was isolated from 18 patients (12.2%) and multidrug-resistant M. tuberculosis was isolated from 12 patients (8.1%). Previous treatment of tuberculosis and the presence of a cavity on the patient's chest computed tomography scan were associated with MDR TB; military rank, smoking habits, and positive acid-fast bacilli smears were not associated with MDR TB. In a multiple logistic regression analysis, previous treatment of tuberculosis was a significant independent risk factor for MDR TB (odds ratio 6.12, 95% confidence interval 1.53-24.46). The prevalence of drug resistant tuberculosis among young soldiers in the Korean military was moderately high and the majority of resistant cases were found in patients who had undergone previous treatment of tuberculosis. Based on our results, we suggest that relapsed tuberculosis cases within communal settings should be cautiously managed until the drug susceptibility tests report is completed, even if previous treatment results were satisfactory.

Original languageEnglish
Pages (from-to)592-595
Number of pages4
JournalJournal of Korean Medical Science
Volume24
Issue number4
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Fingerprint

Multidrug-Resistant Tuberculosis
Military Personnel
Pulmonary Tuberculosis
Tuberculosis
R Factors
Therapeutics
Mycobacterium
Mycobacterium tuberculosis
Drug Resistance
Bacillus
Habits
Thorax
Logistic Models
Smoking
Odds Ratio
Tomography
Regression Analysis
Economics
Confidence Intervals
Acids

Keywords

  • Korea
  • Military personnel
  • Tuberculosis, Multidrug-resistant
  • Tuberculosis, Pulmonary

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting. / Lee, Sei Won; Jeon, Kyeongman; Kim, Kwang Hyun; Min, Kyung-Hoon.

In: Journal of Korean Medical Science, Vol. 24, No. 4, 01.08.2009, p. 592-595.

Research output: Contribution to journalArticle

@article{9f0d4a6d952549c4910bcef5ec97863f,
title = "Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting",
abstract = "The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from January 2001 to December 2006 were enrolled in the study. Drug resistant Mycobacterium tuberculosis was isolated from 18 patients (12.2{\%}) and multidrug-resistant M. tuberculosis was isolated from 12 patients (8.1{\%}). Previous treatment of tuberculosis and the presence of a cavity on the patient's chest computed tomography scan were associated with MDR TB; military rank, smoking habits, and positive acid-fast bacilli smears were not associated with MDR TB. In a multiple logistic regression analysis, previous treatment of tuberculosis was a significant independent risk factor for MDR TB (odds ratio 6.12, 95{\%} confidence interval 1.53-24.46). The prevalence of drug resistant tuberculosis among young soldiers in the Korean military was moderately high and the majority of resistant cases were found in patients who had undergone previous treatment of tuberculosis. Based on our results, we suggest that relapsed tuberculosis cases within communal settings should be cautiously managed until the drug susceptibility tests report is completed, even if previous treatment results were satisfactory.",
keywords = "Korea, Military personnel, Tuberculosis, Multidrug-resistant, Tuberculosis, Pulmonary",
author = "Lee, {Sei Won} and Kyeongman Jeon and Kim, {Kwang Hyun} and Kyung-Hoon Min",
year = "2009",
month = "8",
day = "1",
doi = "10.3346/jkms.2009.24.4.592",
language = "English",
volume = "24",
pages = "592--595",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "4",

}

TY - JOUR

T1 - Multidrug-resistant pulmonary tuberculosis among young Korean soldiers in a communal setting

AU - Lee, Sei Won

AU - Jeon, Kyeongman

AU - Kim, Kwang Hyun

AU - Min, Kyung-Hoon

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from January 2001 to December 2006 were enrolled in the study. Drug resistant Mycobacterium tuberculosis was isolated from 18 patients (12.2%) and multidrug-resistant M. tuberculosis was isolated from 12 patients (8.1%). Previous treatment of tuberculosis and the presence of a cavity on the patient's chest computed tomography scan were associated with MDR TB; military rank, smoking habits, and positive acid-fast bacilli smears were not associated with MDR TB. In a multiple logistic regression analysis, previous treatment of tuberculosis was a significant independent risk factor for MDR TB (odds ratio 6.12, 95% confidence interval 1.53-24.46). The prevalence of drug resistant tuberculosis among young soldiers in the Korean military was moderately high and the majority of resistant cases were found in patients who had undergone previous treatment of tuberculosis. Based on our results, we suggest that relapsed tuberculosis cases within communal settings should be cautiously managed until the drug susceptibility tests report is completed, even if previous treatment results were satisfactory.

AB - The goal of this study was to evaluate the prevalence of first-line anti-tuberculosis drug resistance and risk factors associated with multidrug-resistant tuberculosis (MDR TB) among young soldiers in the Korean military, which has a strict tuberculosis control program. All patients with culture-confirmed pulmonary tuberculosis during their service at the Armed Forces Capital Hospital from January 2001 to December 2006 were enrolled in the study. Drug resistant Mycobacterium tuberculosis was isolated from 18 patients (12.2%) and multidrug-resistant M. tuberculosis was isolated from 12 patients (8.1%). Previous treatment of tuberculosis and the presence of a cavity on the patient's chest computed tomography scan were associated with MDR TB; military rank, smoking habits, and positive acid-fast bacilli smears were not associated with MDR TB. In a multiple logistic regression analysis, previous treatment of tuberculosis was a significant independent risk factor for MDR TB (odds ratio 6.12, 95% confidence interval 1.53-24.46). The prevalence of drug resistant tuberculosis among young soldiers in the Korean military was moderately high and the majority of resistant cases were found in patients who had undergone previous treatment of tuberculosis. Based on our results, we suggest that relapsed tuberculosis cases within communal settings should be cautiously managed until the drug susceptibility tests report is completed, even if previous treatment results were satisfactory.

KW - Korea

KW - Military personnel

KW - Tuberculosis, Multidrug-resistant

KW - Tuberculosis, Pulmonary

UR - http://www.scopus.com/inward/record.url?scp=70350707889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350707889&partnerID=8YFLogxK

U2 - 10.3346/jkms.2009.24.4.592

DO - 10.3346/jkms.2009.24.4.592

M3 - Article

C2 - 19654938

AN - SCOPUS:70350707889

VL - 24

SP - 592

EP - 595

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 4

ER -