Multifunctional chitosan nanoparticles for tumor imaging and therapy

Ji Young Yhee, Heebeom Koo, Dong Eun Lee, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

Chitosan and its derivatives have been widely used for various biomedical applications because of their unique chemical and biological characters. The amine groups in the backbone of chitosan allow chemical modification to change the physical properties of chitosan. Based on hydrophobic or charge interactions with this chitosan polymer backbone, stable self-assembled nanoparticles can be fabricated in aqueous condition. These nanosized structures enable intravenous injection and show large accumulation in tumor tissue, indicating great potential in imaging and drug delivery. The main objective of this review is to introduce various chitosan nanoparticles and their recent applications for tumor diagnosis and therapy.

Original languageEnglish
Title of host publicationAdvances in Polymer Science
Pages139-162
Number of pages24
Volume243
Edition1
DOIs
Publication statusPublished - 2011 Sep 6
Externally publishedYes

Publication series

NameAdvances in Polymer Science
Number1
Volume243
ISSN (Print)00653195

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Keywords

  • Chitosan
  • Molecular imaging
  • Nanoparticle
  • Tumor

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Chemical Engineering(all)

Cite this

Yhee, J. Y., Koo, H., Lee, D. E., Choi, K., Kwon, I. C., & Kim, K. M. (2011). Multifunctional chitosan nanoparticles for tumor imaging and therapy. In Advances in Polymer Science (1 ed., Vol. 243, pp. 139-162). (Advances in Polymer Science; Vol. 243, No. 1). https://doi.org/10.1007/12_2011_119