Multifunctional magnetic gold nanocomposites

Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy

Jaewon Lee, Jaemoon Yang, Hyunju Ko, Seung Jae Oh, Jinyoung Kang, Joo Hiuk Son, Kwangyeol Lee, Sang Wha Lee, Ho Geun Yoon, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra-sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica-gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near-IR laser beam and to image their events through MRI. ERB-conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB-conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near-IR laser-induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelial cancer simultaneously.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalAdvanced Functional Materials
Volume18
Issue number2
DOIs
Publication statusPublished - 2008 Jan 24

Fingerprint

Magnetic resonance
Gold
magnetic resonance
therapy
Nanocomposites
nanocomposites
cancer
gold
Imaging techniques
antibodies
Antibodies
infrared lasers
Cells
Surface plasmon resonance
surface plasmon resonance
cultured cells
Silicon Dioxide
Nanocrystals
Contrast Media
Laser beams

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Science(all)
  • Condensed Matter Physics
  • Physics and Astronomy (miscellaneous)

Cite this

Multifunctional magnetic gold nanocomposites : Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy. / Lee, Jaewon; Yang, Jaemoon; Ko, Hyunju; Oh, Seung Jae; Kang, Jinyoung; Son, Joo Hiuk; Lee, Kwangyeol; Lee, Sang Wha; Yoon, Ho Geun; Suh, Jin Suck; Huh, Yong Min; Haam, Seungjoo.

In: Advanced Functional Materials, Vol. 18, No. 2, 24.01.2008, p. 258-264.

Research output: Contribution to journalArticle

Lee, Jaewon ; Yang, Jaemoon ; Ko, Hyunju ; Oh, Seung Jae ; Kang, Jinyoung ; Son, Joo Hiuk ; Lee, Kwangyeol ; Lee, Sang Wha ; Yoon, Ho Geun ; Suh, Jin Suck ; Huh, Yong Min ; Haam, Seungjoo. / Multifunctional magnetic gold nanocomposites : Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy. In: Advanced Functional Materials. 2008 ; Vol. 18, No. 2. pp. 258-264.
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