Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer

Jaemoon Yang, Choong Hwan Lee, Hyun Ju Ko, Jin Suck Suh, Ho Geun Yoon, Kwangyeol Lee, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

(Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.

Original languageEnglish
Pages (from-to)8836-8839
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number46
DOIs
Publication statusPublished - 2007 Dec 10

Keywords

  • Drug delivery
  • Hybrid composites
  • Imaging agents
  • Magnetic resonance
  • Transmission electron microscopy

ASJC Scopus subject areas

  • Chemistry(all)

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