Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer

Jaemoon Yang; Choong Hwan Lee; Hyun Ju Ko; Jin Suck Suh; Ho Geun Yoon; Kwangyeol Lee; Yong Min Huh; Seungjoo Haam

doi:10.1002/anie.200703554

Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer

Jaemoon Yang, Choong Hwan Lee, Hyun Ju Ko, Jin Suck Suh, Ho Geun Yoon, Kwangyeol Lee, Yong Min Huh, Seungjoo Haam

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

278 Citations (Scopus)

Abstract

(Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe₂O₄ nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T ₂-weighted MR images (top row) and color map (bottom row) of the relaxivity R₂ for NIH3T6.7 and MDA-MB-231 cells.

Original language	English
Pages (from-to)	8836-8839
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	46
DOIs	https://doi.org/10.1002/anie.200703554
Publication status	Published - 2007

Keywords

Drug delivery
Hybrid composites
Imaging agents
Magnetic resonance
Transmission electron microscopy

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200703554

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Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer. / Yang, Jaemoon; Lee, Choong Hwan; Ko, Hyun Ju; Suh, Jin Suck; Yoon, Ho Geun; Lee, Kwangyeol; Huh, Yong Min; Haam, Seungjoo.

In: Angewandte Chemie - International Edition, Vol. 46, No. 46, 2007, p. 8836-8839.

Research output: Contribution to journal › Article › peer-review

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title = "Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer",

abstract = "(Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.",

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author = "Jaemoon Yang and Lee, {Choong Hwan} and Ko, {Hyun Ju} and Suh, {Jin Suck} and Yoon, {Ho Geun} and Kwangyeol Lee and Huh, {Yong Min} and Seungjoo Haam",

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AU - Yang, Jaemoon

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AU - Ko, Hyun Ju

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Lee, Kwangyeol

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2007

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N2 - (Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.

AB - (Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.

KW - Drug delivery

KW - Hybrid composites

KW - Imaging agents

KW - Magnetic resonance

KW - Transmission electron microscopy

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Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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