TY - JOUR
T1 - Multifunctional sonosensitizers in sonodynamic cancer therapy
AU - Son, Subin
AU - Kim, Ji Hyeon
AU - Wang, Xianwen
AU - Zhang, Chuangli
AU - Yoon, Shin A.
AU - Shin, Jinwoo
AU - Sharma, Amit
AU - Lee, Min Hee
AU - Cheng, Liang
AU - Wu, Jiasheng
AU - Kim, Jong Seung
N1 - Funding Information:
This work was supported by the Creative Research Initiatives project (Grant No. 2018R1A3B1052702, J. S. K.), global PhD fellowship (GPF) program of the NRF funded by the Ministry of Science and ICT, Korea (2019H1A2A1074096, J. H. K.), the National Natural Science Foundation of China (Grant No. 21673265), Collaborative Innovation Center of Suzhou Nano Science and Technology, and National Research Foundation of Korea (NRF) (2018R1C1B6006110, M. H. L.). A. S. thanks Department of Biotechnology, New Delhi, for prestigious Ramalingaswami Fellowship 2019 (Grant No. BT/RLF/Re-entry/59/2018).
Publisher Copyright:
© 2020 The Royal Society of Chemistry.
PY - 2020/6/7
Y1 - 2020/6/7
N2 - Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer. However, to be an effective anticancer treatment, it has to overcome limitations, such as low penetration depth, low target specificity, and resistance conferred by the local tumor microenvironment. As a non-invasive technique, low-intensity ultrasound has been widely used in clinical diagnosis as it exhibits deeper penetration into the body compared to light. Recently, sonodynamic therapy (SDT), a combination of low-intensity ultrasound with a chemotherapeutic agent (sonosensitizer), has been explored as a promising alternative for cancer therapy. As all known cancer treatments such as chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, and drug delivery have been advanced independently enough to complement others substantially, the combination of these therapeutic modalities with SDT is opportune. This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy. Also discussed is the potential of SDT in combination with other modalities to address unmet needs in precision medicine.
AB - Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer. However, to be an effective anticancer treatment, it has to overcome limitations, such as low penetration depth, low target specificity, and resistance conferred by the local tumor microenvironment. As a non-invasive technique, low-intensity ultrasound has been widely used in clinical diagnosis as it exhibits deeper penetration into the body compared to light. Recently, sonodynamic therapy (SDT), a combination of low-intensity ultrasound with a chemotherapeutic agent (sonosensitizer), has been explored as a promising alternative for cancer therapy. As all known cancer treatments such as chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, and drug delivery have been advanced independently enough to complement others substantially, the combination of these therapeutic modalities with SDT is opportune. This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy. Also discussed is the potential of SDT in combination with other modalities to address unmet needs in precision medicine.
UR - http://www.scopus.com/inward/record.url?scp=85086284914&partnerID=8YFLogxK
U2 - 10.1039/c9cs00648f
DO - 10.1039/c9cs00648f
M3 - Review article
C2 - 32337527
AN - SCOPUS:85086284914
VL - 49
SP - 3244
EP - 3261
JO - Chemical Society Reviews
JF - Chemical Society Reviews
SN - 0306-0012
IS - 11
ER -